Pyxel is a novel python tool for end-to-end detection chain simulation i.e. from detector optical effects to readout electronics effects. It is an easy-to-use framework to host and pipeline any detector effect model. It is suited for simulating both Charge-Coupled Devices, CMOS Image Sensors and Mercury Cadmium Telluride hybridized arrays. It is conceived as a collaborative tool to promote reusability, knowledge transfer, and reliability in the instrumentation community. We provide a demonstration of Pyxels basic principles, describe newly added capabilities, and give examples of more advanced applications.