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Register a new userPose-dependent weights and Domain Randomization for fully automatic X-ray to CT Registration
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Fully automatic X-ray to CT registration requires a solid initialization to provide an initial alignment within the capture range of existing intensity-based registrations. This work adresses that need by providing a novel automatic initialization, which enables end to end registration. First, a neural network is trained once to detect a set of anatomical landmarks on simulated X-rays. A domain randomization scheme is proposed to enable the network to overcome the challenge of being trained purely on simulated data and run inference on real Xrays. Then, for each patient CT, a patient-specific landmark extraction scheme is used. It is based on backprojecting and clustering the previously trained networks predictions on a set of simulated X-rays. Next, the network is retrained to detect the new landmarks. Finally the combination of network and 3D landmark locations is used to compute the initialization using a perspective-n-point algorithm. During the computation of the pose, a weighting scheme is introduced to incorporate the confidence of the network in detecting the landmarks. The algorithm is evaluated on the pelvis using both real and simulated x-rays. The mean (+-standard deviation) target registration error in millimetres is 4.1 +- 4.3 for simulated X-rays with a success rate of 92% and 4.2 +- 3.9 for real X-rays with a success rate of 86.8%, where a success is defined as a translation error of less than 30mm.
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The goals of this dissertation are to fully automate the image processing techniques needed in the post-operative stage of IGCIP and to perform a thorough analysis of (a) the robustness of the automatic image processing techniques used in IGCIP and (b) assess the sensitivity of the IGCIP process as a whole to individual components. The automatic methods that have been developed include the automatic localization of both closely- and distantly-spaced CI electrode arrays in post-implantation CTs and the automatic selection of electrode configurations based on the stimulation patterns. Together with the existing automatic techniques developed for IGCIP, the proposed automatic methods enable an end-to-end IGCIP process that takes pre- and post-implantation CT images as input and produces a patient-customized electrode configuration as output.
Recently, the use of deep learning techniques to reconstruct computed tomography (CT) images has become a hot research topic, including sinogram domain methods, image domain methods and sinogram domain to image domain methods. All these methods have achieved favorable results. In this article, we have studied the important functions of fully connected layers used in the sinogram domain to image domain approach. First, we present a simple domain mapping neural networks. Then, we analyze the role of the fully connected layers of these networks and visually analyze the weights of the fully connected layers. Finally, by visualizing the weights of the fully connected layer, we found that the main role of the fully connected layer is to implement the back projection function in CT reconstruction. This finding has important implications for the use of deep learning techniques to reconstruct computed tomography (CT) images. For example, since fully connected layer weights need to consume huge memory resources, the back-projection function can be implemented by using analytical algorithms to avoid resource occupation, which can be embedded in the entire network.
There is an increasing need to reconstruct objects in four or more dimensions corresponding to space, time and other independent parameters. The best 4D reconstruction algorithms use regularized iterative reconstruction approaches such as model based iterative reconstruction (MBIR), which depends critically on the quality of the prior modeling. Recently, Plug-and-Play methods have been shown to be an effective way to incorporate advanced prior models using state-of-the-art denoising algorithms designed to remove additive white Gaussian noise (AWGN). However, state-of-the-art denoising algorithms such as BM4D and deep convolutional neural networks (CNNs) are primarily available for 2D and sometimes 3D images. In particular, CNNs are difficult and computationally expensive to implement in four or more dimensions, and training may be impossible if there is no associated high-dimensional training data. In this paper, we present Multi-Slice Fusion, a novel algorithm for 4D and higher-dimensional reconstruction, based on the fusion of multiple low-dimensional denoisers. Our approach uses multi-agent consensus equilibrium (MACE), an extension of Plug-and-Play, as a framework for integrating the multiple lower-dimensional prior models. We apply our method to the problem of 4D cone-beam X-ray CT reconstruction for Non Destructive Evaluation (NDE) of moving parts. This is done by solving the MACE equations using lower-dimensional CNN denoisers implemented in parallel on a heterogeneous cluster. Results on experimental CT data demonstrate that Multi-Slice Fusion can substantially improve the quality of reconstructions relative to traditional 4D priors, while also being practical to implement and train.
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