For many kinds of interventions, such as a new advertisement, marketing intervention, or feature recommendation, it is important to target a specific subset of people for maximizing its benefits at minimum cost or potential harm. However, a key challenge is that no data is available about the effect of such a prospective intervention since it has not been deployed yet. In this work, we propose a split-treatment analysis that ranks the individuals most likely to be positively affected by a prospective intervention using past observational data. Unlike standard causal inference methods, the split-treatment method does not need any observations of the target treatments themselves. Instead it relies on observations of a proxy treatment that is caused by the target treatment. Under reasonable assumptions, we show that the ranking of heterogeneous causal effect based on the proxy treatment is the same as the ranking based on the target treatments effect. In the absence of any interventional data for cross-validation, Split-Treatment uses sensitivity analyses for unobserved confounding to select model parameters. We apply Split-Treatment to both a simulated data and a large-scale, real-world targeting task and validate our discovered rankings via a randomized experiment for the latter.
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