We quantify the disturbance of a quantum state undergoing a sequence of observations, and particularly focus on a weak measurement followed by post-selection and compare these results to the projective counterpart. Taking into account the distinguishability of both, the system and the device, we obtain the exact trade-off between the system state disturbance and the change of the device pointer state. We show that for particular post-selection procedures the coupling strength between the system and the device can be significantly reduced without loosing measurement sensitivity, which is directly transferred to a reduced state disturbance of the system. We observe that a weak measurement alone does not provide this advantage but only in combination with post-selection a significant improvement in terms of increased measurement sensitivity and reduced state disturbance is found. We further show that under realistic experimental conditions this state disturbance is small, whereas the exact post-selection probability is considerably larger than the approximate value given by the overlap of the initial and final state when neglecting the system state disturbance.
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