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Register a new userInterpreting glottal flow dynamics for detecting COVID-19 from voice
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In the pathogenesis of COVID-19, impairment of respiratory functions is often one of the key symptoms. Studies show that in these cases, voice production is also adversely affected -- vocal fold oscillations are asynchronous, asymmetrical and more restricted during phonation. This paper proposes a method that analyzes the differential dynamics of the glottal flow waveform (GFW) during voice production to identify features in them that are most significant for the detection of COVID-19 from voice. Since it is hard to measure this directly in COVID-19 patients, we infer it from recorded speech signals and compare it to the GFW computed from physical model of phonation. For normal voices, the difference between the two should be minimal, since physical models are constructed to explain phonation under assumptions of normalcy. Greater differences implicate anomalies in the bio-physical factors that contribute to the correctness of the physical model, revealing their significance indirectly. Our proposed method uses a CNN-based 2-step attention model that locates anomalies in time-feature space in the difference of the two GFWs, allowing us to infer their potential as discriminative features for classification. The viability of this method is demonstrated using a clinically curated dataset of COVID-19 positive and negative subjects.
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Background: The inability to test at scale has become humanitys Achilles heel in the ongoing war against the COVID-19 pandemic. A scalable screening tool would be a game changer. Building on the prior work on cough-based diagnosis of respiratory diseases, we propose, develop and test an Artificial Intelligence (AI)-powered screening solution for COVID-19 infection that is deployable via a smartphone app. The app, named AI4COVID-19 records and sends three 3-second cough sounds to an AI engine running in the cloud, and returns a result within two minutes. Methods: Cough is a symptom of over thirty non-COVID-19 related medical conditions. This makes the diagnosis of a COVID-19 infection by cough alone an extremely challenging multidisciplinary problem. We address this problem by investigating the distinctness of pathomorphological alterations in the respiratory system induced by COVID-19 infection when compared to other respiratory infections. To overcome the COVID-19 cough training data shortage we exploit transfer learning. To reduce the misdiagnosis risk stemming from the complex dimensionality of the problem, we leverage a multi-pronged mediator centered risk-averse AI architecture. Results: Results show AI4COVID-19 can distinguish among COVID-19 coughs and several types of non-COVID-19 coughs. The accuracy is promising enough to encourage a large-scale collection of labeled cough data to gauge the generalization capability of AI4COVID-19. AI4COVID-19 is not a clinical grade testing tool. Instead, it offers a screening tool deployable anytime, anywhere, by anyone. It can also be a clinical decision assistance tool used to channel clinical-testing and treatment to those who need it the most, thereby saving more lives.
Phonation, or the vibration of the vocal folds, is the primary source of vocalization in the production of voiced sounds by humans. It is a complex bio-mechanical process that is highly sensitive to changes in the speakers respiratory parameters. Since most symptomatic cases of COVID-19 present with moderate to severe impairment of respiratory functions, we hypothesize that signatures of COVID-19 may be observable by examining the vibrations of the vocal folds. Our goal is to validate this hypothesis, and to quantitatively characterize the changes observed to enable the detection of COVID-19 from voice. For this, we use a dynamical system model for the oscillation of the vocal folds, and solve it using our recently developed ADLES algorithm to yield vocal fold oscillation patterns directly from recorded speech. Experimental results on a clinically curated dataset of COVID-19 positive and negative subjects reveal characteristic patterns of vocal fold oscillations that are correlated with COVID-19. We show that these are prominent and discriminative enough that even simple classifiers such as logistic regression yields high detection accuracies using just the recordings of isolated extended vowels.
Robust voice activity detection (VAD) is a challenging task in low signal-to-noise (SNR) environments. Recent studies show that speech enhancement is helpful to VAD, but the performance improvement is limited. To address this issue, here we propose a speech enhancement aided end-to-end multi-task model for VAD. The model has two decoders, one for speech enhancement and the other for VAD. The two decoders share the same encoder and speech separation network. Unlike the direct thought that takes two separated objectives for VAD and speech enhancement respectively, here we propose a new joint optimization objective -- VAD-masked scale-invariant source-to-distortion ratio (mSI-SDR). mSI-SDR uses VAD information to mask the output of the speech enhancement decoder in the training process. It makes the VAD and speech enhancement tasks jointly optimized not only at the shared encoder and separation network, but also at the objective level. It also satisfies real-time working requirement theoretically. Experimental results show that the multi-task method significantly outperforms its single-task VAD counterpart. Moreover, mSI-SDR outperforms SI-SDR in the same multi-task setting.
Mel-frequency filter bank (MFB) based approaches have the advantage of learning speech compared to raw spectrum since MFB has less feature size. However, speech generator with MFB approaches require additional vocoder that needs a huge amount of computation expense for training process. The additional pre/post processing such as MFB and vocoder is not essential to convert real human speech to others. It is possible to only use the raw spectrum along with the phase to generate different style of voices with clear pronunciation. In this regard, we propose a fast and effective approach to convert realistic voices using raw spectrum in a parallel manner. Our transformer-based model architecture which does not have any CNN or RNN layers has shown the advantage of learning fast and solved the limitation of sequential computation of conventional RNN. In this paper, we introduce a vocoder-free end-to-end voice conversion method using transformer network. The presented conversion model can also be used in speaker adaptation for speech recognition. Our approach can convert the source voice to a target voice without using MFB and vocoder. We can get an adapted MFB for speech recognition by multiplying the converted magnitude with phase. We perform our voice conversion experiments on TIDIGITS dataset using the metrics such as naturalness, similarity, and clarity with mean opinion score, respectively.
The neural network (NN) based singing voice synthesis (SVS) systems require sufficient data to train well and are prone to over-fitting due to data scarcity. However, we often encounter data limitation problem in building SVS systems because of high data acquisition and annotation costs. In this work, we propose a Perceptual Entropy (PE) loss derived from a psycho-acoustic hearing model to regularize the network. With a one-hour open-source singing voice database, we explore the impact of the PE loss on various mainstream sequence-to-sequence models, including the RNN-based, transformer-based, and conformer-based models. Our experiments show that the PE loss can mitigate the over-fitting problem and significantly improve the synthesized singing quality reflected in objective and subjective evaluations.
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