We introduce a generic algorithm to determine the time delays and spacecraft (S/C) positions to compose any time-delay interferometry (TDI) channel in the dynamical case and evaluate its sensitivity by using a full numerical method. We select 11 second-generation TDI channels constructed from four approaches and investigate their gravitational wave responses, noise levels, and averaged sensitivities under a numerical LISA orbit. The sensitivities of selected channels are various especially for frequencies lower than 20 mHz. The optimal channel A$_2$ (or equivalently E$_2$) combined from second-generation Michelson TDI channels (X$_1$, X$_2$, and X$_3$) achieves the best sensitivity among the channels, while the Sagnac $alpha_1$ channel shows the worse sensitivity. Multiple channels show better sensitivities at some characteristic frequencies compared to the fiducial X$_1$ channel. The joint $mathrm{A_2+E_2+T_2}$ observation not only enhances the sensitivity of the X$_1$ channel by a factor of $sqrt{2}$ to 2 but also improves the capacity of sky coverage.
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