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Register a new userForgery Blind Inspection for Detecting Manipulations of Gel Electrophoresis Images
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Recently, falsified images have been found in papers involved in research misconducts. However, although there have been many image forgery detection methods, none of them was designed for molecular-biological experiment images. In this paper, we proposed a fast blind inquiry method, named FBI$_{GEL}$, for integrity of images obtained from two common sorts of molecular experiments, i.e., western blot (WB) and polymerase chain reaction (PCR). Based on an optimized pseudo-background capable of highlighting local residues, FBI$_{GEL}$ can reveal traceable vestiges suggesting inappropriate local modifications on WB/PCR images. Additionally, because the optimized pseudo-background is derived according to a closed-form solution, FBI$_{GEL}$ is computationally efficient and thus suitable for large scale inquiry tasks for WB/PCR image integrity. We applied FBI$_{GEL}$ on several papers questioned by the public on textbf{PUBPEER}, and our results show that figures of those papers indeed contain doubtful unnatural patterns.
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Artificial Intelligence (AI)-powered pathology is a revolutionary step in the world of digital pathology and shows great promise to increase both diagnosis accuracy and efficiency. However, defocus and motion blur can obscure tissue or cell characteristics hence compromising AI algorithmsaccuracy and robustness in analyzing the images. In this paper, we demonstrate a deep-learning-based approach that can alleviate the defocus and motion blur of a microscopic image and output a sharper and cleaner image with retrieved fine details without prior knowledge of the blur type, blur extent and pathological stain. In this approach, a deep learning classifier is first trained to identify the image blur type. Then, two encoder-decoder networks are trained and used alone or in combination to deblur the input image. It is an end-to-end approach and introduces no corrugated artifacts as traditional blind deconvolution methods do. We test our approach on different types of pathology specimens and demonstrate great performance on image blur correction and the subsequent improvement on the diagnosis outcome of AI algorithms.
the MIAPE Gel Electrophoresis (MIAPE-GE) guidelines specify the minimum information that should be provided when reporting the use of n-dimensional gel electrophoresis in a proteomics experiment. Developed through a joint effort between the gel-based analysis working group of the Human Proteome Organisations Proteomics Standards Initiative (HUPO-PSI; http://www.psidev.info/) and the wider proteomics community, they constitute one part of the overall Minimum Information about a Proteomics Experiment (MIAPE) documentation system published last August in Nature Biotechnology
Ground Penetrating Radar (GPR) is an effective non-destructive evaluation (NDE) device for inspecting and surveying subsurface objects (i.e., rebars, utility pipes) in complex environments. However, the current practice for GPR data collection requires a human inspector to move a GPR cart along pre-marked grid lines and record the GPR data in both X and Y directions for post-processing by 3D GPR imaging software. It is time-consuming and tedious work to survey a large area. Furthermore, identifying the subsurface targets depends on the knowledge of an experienced engineer, who has to make manual and subjective interpretation that limits the GPR applications, especially in large-scale scenarios. In addition, the current GPR imaging technology is not intuitive, and not for normal users to understand, and not friendly to visualize. To address the above challenges, this paper presents a novel robotic system to collect GPR data, interpret GPR data, localize the underground utilities, reconstruct and visualize the underground objects dense point cloud model in a user-friendly manner. This system is composed of three modules: 1) a vision-aided Omni-directional robotic data collection platform, which enables the GPR antenna to scan the target area freely with an arbitrary trajectory while using a visual-inertial-based positioning module tags the GPR measurements with positioning information; 2) a deep neural network (DNN) migration module to interpret the raw GPR B-scan image into a cross-section of object model; 3) a DNN-based 3D reconstruction method, i.e., GPRNet, to generate underground utility model represented as fine 3D point cloud. Comparative studies on synthetic and field GPR raw data with various incompleteness and noise are performed.
Image denoising is the process of removing noise from noisy images, which is an image domain transferring task, i.e., from a single or several noise level domains to a photo-realistic domain. In this paper, we propose an effective image denoising method by learning two image priors from the perspective of domain alignment. We tackle the domain alignment on two levels. 1) the feature-level prior is to learn domain-invariant features for corrupted images with different level noise; 2) the pixel-level prior is used to push the denoised images to the natural image manifold. The two image priors are based on $mathcal{H}$-divergence theory and implemented by learning classifiers in adversarial training manners. We evaluate our approach on multiple datasets. The results demonstrate the effectiveness of our approach for robust image denoising on both synthetic and real-world noisy images. Furthermore, we show that the feature-level prior is capable of alleviating the discrepancy between different level noise. It can be used to improve the blind denoising performance in terms of distortion measures (PSNR and SSIM), while pixel-level prior can effectively improve the perceptual quality to ensure the realistic outputs, which is further validated by subjective evaluation.
Blind image deblurring is an important yet very challenging problem in low-level vision. Traditional optimization based methods generally formulate this task as a maximum-a-posteriori estimation or variational inference problem, whose performance highly relies on the handcraft priors for both the latent image and the blur kernel. In contrast, recent deep learning methods generally learn, from a large collection of training images, deep neural networks (DNNs) directly mapping the blurry image to the clean one or to the blur kernel, paying less attention to the physical degradation process of the blurry image. In this paper, we present a deep variational Bayesian framework for blind image deblurring. Under this framework, the posterior of the latent clean image and blur kernel can be jointly estimated in an amortized inference fashion with DNNs, and the involved inference DNNs can be trained by fully considering the physical blur model, together with the supervision of data driven priors for the clean image and blur kernel, which is naturally led to by the evidence lower bound objective. Comprehensive experiments are conducted to substantiate the effectiveness of the proposed framework. The results show that it can not only achieve a promising performance with relatively simple networks, but also enhance the performance of existing DNNs for deblurring.
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