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Register a new userAutomatic selection of eye tracking variables in visual categorization in adults and infants
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Visual categorization and learning of visual categories exhibit early onset, however the underlying mechanisms of early categorization are not well understood. The main limiting factor for examining these mechanisms is the limited duration of infant cooperation (10-15 minutes), which leaves little room for multiple test trials. With its tight link to visual attention, eye tracking is a promising method for getting access to the mechanisms of category learning. But how should researchers decide which aspects of the rich eye tracking data to focus on? To date, eye tracking variables are generally handpicked, which may lead to biases in the eye tracking data. Here, we propose an automated method for selecting eye tracking variables based on analyses of their usefulness to discriminate learners from non-learners of visual categories. We presented infants and adults with a category learning task and tracked their eye movements. We then extracted an over-complete set of eye tracking variables encompassing durations, probabilities, latencies, and the order of fixations and saccadic eye movements. We compared three statistical techniques for identifying those variables among this large set that are useful for discriminating learners form non-learners: ANOVA ranking, Bayes ranking, and L1 regularized logistic regression. We found remarkable agreement between these methods in identifying a small set of discriminant variables. Moreover, the same eye tracking variables allow us to classify category learners from non-learners among adults and 6- to 8-month-old infants with accuracies above 71%.
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Infants spontaneous and voluntary movements mirror developmental integrity of brain networks since they require coordinated activation of multiple sites in the central nervous system. Accordingly, early detection of infants with atypical motor development holds promise for recognizing those infants who are at risk for a wide range of neurodevelopmental disorders (e.g., cerebral palsy, autism spectrum disorders). Previously, novel wearable technology has shown promise for offering efficient, scalable and automated methods for movement assessment in adults. Here, we describe the development of an infant wearable, a multi-sensor smart jumpsuit that allows mobile accelerometer and gyroscope data collection during movements. Using this suit, we first recorded play sessions of 22 typically developing infants of approximately 7 months of age. These data were manually annotated for infant posture and movement based on video recordings of the sessions, and using a novel annotation scheme specifically designed to assess the overall movement pattern of infants in the given age group. A machine learning algorithm, based on deep convolutional neural networks (CNNs) was then trained for automatic detection of posture and movement classes using the data and annotations. Our experiments show that the setup can be used for quantitative tracking of infant movement activities with a human equivalent accuracy, i.e., it meets the human inter-rater agreement levels in infant posture and movement classification. We also quantify the ambiguity of human observers in analyzing infant movements, and propose a method for utilizing this uncertainty for performance improvements in training of the automated classifier. Comparison of different sensor configurations also shows that four-limb recording leads to the best performance in posture and movement classification.
We present an algorithmic and visual grouping of participants and eye-tracking metrics derived from recorded eye-tracking data. Our method utilizes two well-established visualization concepts. First, parallel coordinates are used to provide an overview of the used metrics, their interactions, and similarities, which helps select suitable metrics that describe characteristics of the eye-tracking data. Furthermore, parallel coordinates plots enable an analyst to test the effects of creating a combination of a subset of metrics resulting in a newly derived eye-tracking metric. Second, a similarity matrix visualization is used to visually represent the affine combination of metrics utilizing an algorithmic grouping of subjects that leads to distinct visual groups of similar behavior. To keep the diagrams of the matrix visualization simple and understandable, we visually encode our eye-tracking data into the cells of a similarity matrix of participants. The algorithmic grouping is performed with a clustering based on the affine combination of metrics, which is also the basis for the similarity value computation of the similarity matrix. To illustrate the usefulness of our visualization, we applied it to an eye-tracking data set involving the reading behavior of metro maps of up to 40 participants. Finally, we discuss limitations and scalability issues of the approach focusing on visual and perceptual issues.
Preterm infants are at high risk of developing brain injury in the first days of life as a consequence of poor cerebral oxygen delivery. Near-infrared spectroscopy (NIRS) is an established technology developed to monitor regional tissue oxygenation. Detailed waveform analysis of the cerebral NIRS signal could improve the clinical utility of this method in accurately predicting brain injury. Frequent transient cerebral oxygen desaturations are commonly observed in extremely preterm infants, yet their clinical significance remains unclear. The aim of this study was to examine and compare the performance of two distinct approaches in isolating and extracting transient deflections within NIRS signals. We optimized three different simultaneous low-pass filtering and total variation denoising (LPF_TVD) methods and compared their performance with a recently proposed method that uses singular-spectrum analysis and the discrete cosine transform (SSA_DCT). Parameters for the LPF_TVD methods were optimized over a grid search using synthetic NIRS-like signals. The SSA_DCT method was modified with a post-processing procedure to increase sparsity in the extracted components. Our analysis, using a synthetic NIRS-like dataset, showed that a LPF_TVD method outperformed the modified SSA_DCT method: median mean-squared error of 0.97 (95% CI: 0.86 to 1.07) was lower for the LPF_TVD method compared to the modified SSA_DCT method of 1.48 (95% CI: 1.33 to 1.63), P<0.001. The dual low-pass filter and total variation denoising methods are considerably more computational efficient, by 3 to 4 orders of magnitude, than the SSA_DCT method. More research is needed to examine the efficacy of these methods in extracting oxygen desaturation in real NIRS signals.
1. Advances in tracking technology have led to an exponential increase in animal location data, greatly enhancing our ability to address interesting questions in movement ecology, but also presenting new challenges related to data manage- ment and analysis. 2. Step-Selection Functions (SSFs) are commonly used to link environmental covariates to animal location data collected at fine temporal resolution. SSFs are estimated by comparing observed steps connecting successive animal locations to random steps, using a likelihood equivalent of a Cox proportional hazards model. By using common statistical distributions to model step length and turn angle distributions, and including habitat- and movement-related covariates (functions of distances between points, angular deviations), it is possible to make inference regarding habitat selection and movement processes, or to control one process while investigating the other. The fitted model can also be used to estimate utilization distributions and mechanistic home ranges. 3. Here, we present the R-package amt (animal movement tools) that allows users to fit SSFs to data and to simulate space use of animals from fitted models. The amt package also provides tools for managing telemetry data. 4. Using fisher (Pekania pennanti ) data as a case study, we illustrate a four-step approach to the analysis of animal movement data, consisting of data management, exploratory data analysis, fitting of models, and simulating from fitted models.
To support and guide an extensive experimental research into systems biology of signaling pathways, increasingly more mechanistic models are being developed with hopes of gaining further insight into biological processes. In order to analyse these models, computational and statistical techniques are needed to estimate the unknown kinetic parameters. This chapter reviews methods from frequentist and Bayesian statistics for estimation of parameters and for choosing which model is best for modeling the underlying system. Approximate Bayesian Computation (ABC) techniques are introduced and employed to explore different hypothesis about the JAK-STAT signaling pathway.
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