Power grid data are going big with the deployment of various sensors. The big data in power grids creates huge opportunities for applying artificial intelligence technologies to improve resilience and reliability. This paper introduces multiple real-world applications based on artificial intelligence to improve power grid situational awareness and resilience. These applications include event identification, inertia estimation, event location and magnitude estimation, data authentication, control, and stability assessment. These applications are operating on a real-world system called FNET-GridEye, which is a wide-area measurement network and arguably the world-largest cyber-physical system that collects power grid big data. These applications showed much better performance compared with conventional approaches and accomplished new tasks that are impossible to realized using conventional technologies. These encouraging results demonstrate that combining power grid big data and artificial intelligence can uncover and capture the non-linear correlation between power grid data and its stabilities indices and will potentially enable many advanced applications that can significantly improve power grid resilience.