Magnetic reconnection underlies many explosive phenomena in the heliosphere and in laboratory plasmas. The new research capabilities in theory/simulations, observations, and laboratory experiments provide the opportunity to solve the grand scientific challenges summarized in this whitepaper. Success will require enhanced and sustained investments from relevant funding agencies, increased interagency/international partnerships, and close collaborations of the solar, heliospheric, and laboratory plasma communities. These investments will deliver transformative progress in understanding magnetic reconnection and related explosive phenomena including space weather events.