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Enhancing and Learning Denoiser without Clean Reference

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 Added by Rui Zhao
 Publication date 2020
and research's language is English




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Recent studies on learning-based image denoising have achieved promising performance on various noise reduction tasks. Most of these deep denoisers are trained either under the supervision of clean references, or unsupervised on synthetic noise. The assumption with the synthetic noise leads to poor generalization when facing real photographs. To address this issue, we propose a novel deep image-denoising method by regarding the noise reduction task as a special case of the noise transference task. Learning noise transference enables the network to acquire the denoising ability by observing the corrupted samples. The results on real-world denoising benchmarks demonstrate that our proposed method achieves promising performance on removing realistic noises, making it a potential solution to practical noise reduction problems.



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Purpose: To develop a strategy for training a physics-guided MRI reconstruction neural network without a database of fully-sampled datasets. Theory and Methods: Self-supervised learning via data under-sampling (SSDU) for physics-guided deep learning (DL) reconstruction partitions available measurements into two disjoint sets, one of which is used in the data consistency units in the unrolled network and the other is used to define the loss for training. The proposed training without fully-sampled data is compared to fully-supervised training with ground-truth data, as well as conventional compressed sensing and parallel imaging methods using the publicly available fastMRI knee database. The same physics-guided neural network is used for both proposed SSDU and supervised training. The SSDU training is also applied to prospectively 2-fold accelerated high-resolution brain datasets at different acceleration rates, and compared to parallel imaging. Results: Results on five different knee sequences at acceleration rate of 4 shows that proposed self-supervised approach performs closely with supervised learning, while significantly outperforming conventional compressed sensing and parallel imaging, as characterized by quantitative metrics and a clinical reader study. The results on prospectively sub-sampled brain datasets, where supervised learning cannot be employed due to lack of ground-truth reference, show that the proposed self-supervised approach successfully perform reconstruction at high acceleration rates (4, 6 and 8). Image readings indicate improved visual reconstruction quality with the proposed approach compared to parallel imaging at acquisition acceleration. Conclusion: The proposed SSDU approach allows training of physics-guided DL-MRI reconstruction without fully-sampled data, while achieving comparable results with supervised DL-MRI trained on fully-sampled data.
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Computed tomography (CT) has played a vital role in medical diagnosis, assessment, and therapy planning, etc. In clinical practice, concerns about the increase of X-ray radiation exposure attract more and more attention. To lower the X-ray radiation, low-dose CT is often used in certain scenarios, while it will induce the degradation of CT image quality. In this paper, we proposed a training method that trained denoising neural networks without any paired clean data. we trained the denoising neural network to map one noise LDCT image to its two adjacent LDCT images in a singe 3D thin-layer low-dose CT scanning, simultaneously In other words, with some latent assumptions, we proposed an unsupervised loss function with the integration of the similarity between adjacent CT slices in 3D thin-layer lowdose CT to train the denoising neural network in an unsupervised manner. For 3D thin-slice CT scanning, the proposed virtual supervised loss function was equivalent to a supervised loss function with paired noisy and clean samples when the noise in the different slices from a single scan was uncorrelated and zero-mean. Further experiments on Mayo LDCT dataset and a realistic pig head were carried out and demonstrated superior performance over existing unsupervised methods.
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