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Register a new userLow-coherence optical diffraction tomography using a ferroelectric liquid crystal spatial light modulator
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Optical diffraction tomography (ODT) is a three-dimensional (3D) label-free imaging technique. The 3D refractive index distribution of a sample can be reconstructed from multiple two-dimensional optical field images via ODT. Herein, we introduce a temporally low-coherence ODT technique using a ferroelectric liquid crystal spatial light modulator (FLC SLM). The fast binary-phase modulation provided by the FLC SLM ensures a high spatiotemporal resolution with considerably reduced coherent noise. We demonstrate the performance of the proposed system using various samples, including colloidal microspheres and live epithelial cells.
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We report a new method to generate uniform large-scale optical focus arrays (LOFAs). By identifying and removing undesired phase rotation in the iterative Fourier-transform algorithm (IFTA), our approach rapidly produces computer-generated holograms of highly uniform LOFAs. The new algorithm also shows faster compensation of system-induced LOFA intensity inhomogeneity than the conventional IFTA. After just three adaptive correction steps, we demonstrate LOFAs consisting of $mathcal{O}(10^3)$ optical foci with $> 98 %$ intensity uniformity.
We propose and experimentally demonstrate temporally low-coherent optical diffraction tomography (ODT) based on angle-scanning Mach-Zehnder interferometry. Using a digital micromirror device based on diffractive tilting, we successfully maintain full-field interference of incoherent light during every scan sequence. The ODT reconstruction principles for temporally incoherent illuminations are thoroughly reviewed and developed. Several limitations of incoherent illumination are also discussed, such as the nondispersive assumption, optical sectioning capacity, and illumination angle limitation. Using the proposed setup and reconstruction algorithms, we successfully demonstrate low-coherent ODT imaging of microspheres, human red blood cells, and eukaryotic cells.
Spatial light modulators (SLMs) are devices for modulating amplitude, phase or polarization of a light beam on demand. Such devices have been playing an indispensable inuence in many areas from our daily entertainments to scientific researches. In the past decades, the SLMs have been mainly operated in electrical addressing (EASLM) manner, wherein the writing images are created and loaded via conventional electronic interfaces. However, adoption of pixelated electrodes puts limits on both resolution and efficiency of the EASLMs. Here, we present an optically addressed SLM based on a nonlinear metasurface (MS-OASLM), by which signal light is directly modulated by another writing beam requiring no electrode. The MS-OASLM shows unprecedented compactness and is 400 nm in total thickness benefitting from the outstanding nonlinearity of the metasurface. And their subwavelength feature size enables a high resolution up to 250 line pairs per millimeter, which is more than one order of magnitude better than any currently commercial SLMs. Such MS-OASLMs could provide opportunities to develop the next generation of high resolution displays and all-optical information processing technologies.
Spatial modes of light provide a high-dimensional space that can be used to encode both classical and quantum information. Current approaches for dynamically generating and measuring these modes are slow, due to the need to reconfigure a high-resolution phase mask such as a spatial light modulator or digital micromirror device. The process of updating the spatial mode of light can be greatly accelerated by multiplexing a set of static phase masks with a fast, image-preserving optical switch, such as an acousto-optic modulator (AOM). We experimentally realize this approach, using a double-pass AOM to generate one of five orbital angular momentum states with a switching rate of up to 500 kHz. We then apply this system to perform fast quantum state tomography of spatial modes of light in a 2-dimensional Hilbert space, by projecting the unknown state onto six spatial modes comprising three mutually unbiased bases. We are able to reconstruct arbitrary states in under 1 ms with an average fidelity of 96.9%.
We report optical brain imaging using a semi-transparent organic light-emitting diode (OLED) based on the orange light-emitting polymer (LEP) Livilux PDO-124. The OLED serves as a compact, extended light source which is capable of uniformly illuminating the cortical surface when placed across a burr hole in the skull. Since all layers of the OLED are substantially transparent to photons with energies below the optical gap of the LEP, light emitted or reflected by the cortical surface may be efficiently transmitted through the OLED and into the objective lens of a low magnification microscope (macroscope). The OLED may be placed close to the cortical surface, providing efficient coupling of incident light into the brain cavity; furthermore, the macroscope may be placed close to the upper surface of the OLED, enabling efficient collection of reflected/emitted light from the cortical surface. Hence the use of a semi-transparent OLED simplifies the optical setup, while at the same time maintaining high sensitivity. The OLED is applied here to one of the most demanding forms of optical brain imaging, namely extrinsic optical imaging involving a voltage sensitive dye (VSD). Specifically, we carry out functional imaging of the primary visual cortex (V1) of a rat, using the voltage sensitive dye RH-1691 as a reporter. Imaging through the OLED light-source, we are able to resolve small (~ 0.1 %) changes in the fluorescence intensity of the dye due to changes in the neuronal membrane potential following a visual stimulus. Results are obtained on a single trial basis -- i.e. without averaging over multiple measurements -- with a time-resolution of ten milliseconds.
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