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Register a new userMIMIC modelling with instrumental variables: A 2SLS-MIMIC approach
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Added by
Andrej Srakar
Publication date
2020
fields
Mathematical Statistics
and research's language is
English
Authors
Andrej Srakar
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Multiple Indicators Multiple Causes (MIMIC) models are type of structural equation models, a theory-based approach to confirm the influence of a set of exogenous causal variables on the latent variable, and also the effect of the latent variable on observed indicator variables. In a common MIMIC model, multiple indicators reflect the underlying latent variables/factors, and the multiple causes (observed predictors) affect latent variables/factors. Basic assumptions of MIMIC are clearly violated in case of a variable being both an indicator and a cause, i.e. in the presence of reverse causality. Furthermore, the model is then unidentified. To resolve the situation, which can arise frequently, and as MIMIC estimation lacks closed form solutions for parameters we utilize a version of Bollens (1996) 2SLS estimator for structural equation models combined with Joreskog (1970)s method of the analysis of covariance structures to derive a new, 2SLS estimator for MIMIC models. Our 2SLS empirical estimation is based on static MIMIC specification but we point also to dynamic/error-correction MIMIC specification and 2SLS solution for it. We derive basic asymptotic theory for static 2SLS-MIMIC, present a simulation study and apply findings to an interesting empirical case of estimating precarious status of older workers (using dataset of Survey of Health, Ageing and Retirement in Europe) which solves an important issue of the definition of precarious work as a multidimensional concept, not modelled adequately so far.
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Robust machine learning relies on access to data that can be used with standardized frameworks in important tasks and the ability to develop models whose performance can be reasonably reproduced. In machine learning for healthcare, the community faces reproducibility challenges due to a lack of publicly accessible data and a lack of standardized data processing frameworks. We present MIMIC-Extract, an open-source pipeline for transforming raw electronic health record (EHR) data for critical care patients contained in the publicly-available MIMIC-III database into dataframes that are directly usable in common machine learning pipelines. MIMIC-Extract addresses three primary challenges in making complex health records data accessible to the broader machine learning community. First, it provides standardized data processing functions, including unit conversion, outlier detection, and aggregating semantically equivalent features, thus accounting for duplication and reducing missingness. Second, it preserves the time series nature of clinical data and can be easily integrated into clinically actionable prediction tasks in machine learning for health. Finally, it is highly extensible so that other researchers with related questions can easily use the same pipeline. We demonstrate the utility of this pipeline by showcasing several benchmark tasks and baseline results.
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