We investigate integrability of Euler-Lagrange equations associated with 2D second-order Lagrangians of the form begin{equation*} int f(u_{xx},u_{xy},u_{yy}) dxdy. end{equation*} By deriving integrability conditions for the Lagrangian density $f$, examples of integrable Lagrangians expressible via elementary functions, Jacobi theta functions and dilogarithms are constructed. A link of second-order integrable Lagrangians to WDVV equations is established. Generalisations to 3D second-order integrable Lagrangians are also discussed.