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Vocal markers from sustained phonation in Huntingtons Disease

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 Added by Rachid Riad
 Publication date 2020
and research's language is English




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Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntingtons Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory impairments as potential clinical markers and propose them for both diagnosis and gene carriers follow-up. We used two sets of features: Phonatory features and Modulation Power Spectrum Features. We found that phonation is not sufficient for the identification of sub-clinical disorders of premanifest gene carriers. According to our regression results, Phonatory features are suitable for the predictions of clinical performance in Huntingtons Disease.



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