Nanoscale semiconductor technology has been a key enabler of the computing revolution. It has done so via advances in new materials and manufacturing processes that resulted in the size of the basic building block of computing systems - the logic switch and memory devices - being reduced into the nanoscale regime. Nanotechnology has provided increased computing functionality per unit volume, energy, and cost. In order for computing systems to continue to deliver substantial benefits for the foreseeable future to society at large, it is critical that the very notion of computing be examined in the light of nanoscale realities. In particular, one needs to ask what it means to compute when the very building block - the logic switch - no longer exhibits the level of determinism required by the von Neumann architecture. There needs to be a sustained and heavy investment in a nation-wide Vertically Integrated Semiconductor Ecosystem (VISE). VISE is a program in which research and development is conducted seamlessly across the entire compute stack - from applications, systems and algorithms, architectures, circuits and nanodevices, and materials. A nation-wide VISE provides clear strategic advantages in ensuring the USs global superiority in semiconductors. First, a VISE provides the highest quality seed-corn for nurturing transformative ideas that are critically needed today in order for nanotechnology-inspired computing to flourish. It does so by dramatically opening up new areas of semiconductor research that are inspired and driven by new application needs. Second, a VISE creates a very high barrier to entry from foreign competitors because it is extremely hard to establish, and even harder to duplicate.