Performing efficient quantum computer tuneup and calibration is essential for growth in system complexity. In this work we explore the link between facilitating such capabilities and the underlying architecture of the physical hardware. We focus on the specific challenge of measuring (``mapping) spatially inhomogeneous quasi-static calibration errors using spectator qubits dedicated to the task of sensing and calibration. We introduce a novel architectural concept for such spectator qubits: arranging them spatially according to prescriptions from optimal 2D approximation theory. We show that this insight allows for efficient reconstruction of inhomogeneities in qubit calibration, focusing on the specific example of frequency errors which may arise from fabrication variances or ambient magnetic fields. Our results demonstrate that optimal interpolation techniques display near optimal error-scaling in cases where the measured characteristic (here the qubit frequency) varies smoothly, and we probe the limits of these benefits as a function of measurement uncertainty. For more complex spatial variations, we demonstrate that the NMQA formalism for adaptive measurement and noise filtering outperforms optimal interpolation techniques in isolation, and crucially, can be combined with insights from optimal interpolation theory to produce a general purpose protocol.
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