General-education college astronomy courses offer instructors both a unique audience and a unique challenge. For many students, such a course may be their first time encountering a standalone astronomy class, and it is also likely one of the last science courses they will take. Thus, in a single semester, primary course goals often include both imparting knowledge about the Universe and giving students some familiarity with the processes of science. In traditional course environments, students often compartmentalize information into separate life files and course files rather than integrating information into a coherent framework. The astronomy course created through this project, taught at the University of Arizona in Spring 2019, was designed around inclusivity-driven guiding principles that help students engage with course content in ways that are meaningful, relevant, and accessible. Our course bridges the gap between students life and course files, encourages and respects diverse points of view, and empowers students to connect course content with their personal lives and identities. In this paper, we provide insight into the guiding principles that informed our course design and share research results on the effectiveness of the instructional strategies and assessment techniques implemented in the course.