We study the isospin mass differences of singly heavy baryons, based on a pion mean-field approach. We consider both the electromagnetic interactions and the hadronic contributions that arise from the mass difference of the up and down quarks. The relevant parameters have been already fixed by the baryon octet. In addition, we introduce the strong hyperfine interactions between the light quarks inside a chiral soliton and the Coulomb interactions between the chiral soliton and a heavy quark. The numerical results are in good agreement with the experimental data. In particular, the results for the neutral mass relations, which contain only the electromagnetic contributions, are in remarkable agreement with the data, which implies that the pion mean field approach provides a good description of the singly heavy baryons.