We present a polarization-insensitive metasurface processor to perform spatial asymmetric filtering of an incident optical beam, thereby allowing for real-time parallel optical processing. To enable massive parallel processing, we introduce a novel Multi Input-Multi Output (MIMO) computational metasurface with an asymmetric optical response that can perform spatial differentiation on two distinct input signals regardless of their polarization. In our scenario, two distinct signals set in x and y directions, parallel and perpendicular to the incident plane, illuminate simultaneously the metasurface processor, and the resulting differentiated signals are separated from each other via appropriate Spatial Low Pass Filters (SLPF). By leveraging Generalized Sheet Transition Conditions (GSTCs) and surface susceptibility tensors, we design an asymmetric meta-atom augmented with normal susceptibilitiesto reach asymmetric optical response at normal beam illumination. Proof-of-principle simulations are also reported along with the successful realization of signal processing functions. The proposed metasurface overcomes major shortcomings imposed by previous studies such as large architectures arising from the need of additional subblocks, slow responses, and most importantly, supporting only a single input with a given polarization. Our results set the path for future developments of material-based analog computing using efficient and easy-to-fabricate MIMO processors for compact, fast, and integrable computing elements without any Fourier lens.