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Register a new userCOVID-19: Strategies for Allocation of Test Kits
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Added by
Arpita Biswas
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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With the increasing spread of COVID-19, it is important to systematically test more and more people. The current strategy for test-kit allocation is mostly rule-based, focusing on individuals having (a) symptoms for COVID-19, (b) travel history or (c) contact history with confirmed COVID-19 patients. Such testing strategy may miss out on detecting asymptomatic individuals who got infected via community spread. Thus, it is important to allocate a separate budget of test-kits per day targeted towards preventing community spread and detecting new cases early on. In this report, we consider the problem of allocating test-kits and discuss some solution approaches. We believe that these approaches will be useful to contain community spread and detect new cases early on. Additionally, these approaches would help in collecting unbiased data which can then be used to improve the accuracy of machine learning models trained to predict COVID-19 infections.
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Efficient testing and vaccination protocols are critical aspects of epidemic management. To study the optimal allocation of limited testing and vaccination resources in a heterogeneous contact network of interacting susceptible, recovered, and infected individuals, we present a degree-based testing and vaccination model for which we use control-theoretic methods to derive optimal testing and vaccination policies. Within our framework, we find that optimal intervention policies first target high-degree nodes before shifting to lower-degree nodes in a time-dependent manner. Using such optimal policies, it is possible to delay outbreaks and reduce incidence rates to a greater extent than uniform and reinforcement-learning-based interventions, particularly on certain scale-free networks.
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to a wide range of non-pharmaceutical interventions being implemented around the world to curb transmission. However, the economic and social costs of some of these measures, especially lockdowns, has been high. An alternative and widely discussed public health strategy for the COVID-19 pandemic would have been to shield those most vulnerable to COVID-19, while allowing infection to spread among lower risk individuals with the aim of reaching herd immunity. Here we retrospectively explore the effectiveness of this strategy, showing that even under the unrealistic assumption of perfect shielding, hospitals would have been rapidly overwhelmed with many avoidable deaths among lower risk individuals. Crucially, even a small (20%) reduction in the effectiveness of shielding would have likely led to a large increase (>150%) in the number of deaths compared to perfect shielding. Our findings demonstrate that shielding the vulnerable while allowing infections to spread among the wider population would not have been a viable public health strategy for COVID-19, and is unlikely to be effective for future pandemics.
The world has seen in 2020 an unprecedented global outbreak of SARS-CoV-2, a new strain of coronavirus, causing the COVID-19 pandemic, and radically changing our lives and work conditions. Many scientists are working tirelessly to find a treatment and a possible vaccine. Furthermore, governments, scientific institutions and companies are acting quickly to make resources available, including funds and the opening of large-volume data repositories, to accelerate innovation and discovery aimed at solving this pandemic. In this paper, we develop a novel automated theme-based visualisation method, combining advanced data modelling of large corpora, information mapping and trend analysis, to provide a top-down and bottom-up browsing and search interface for quick discovery of topics and research resources. We apply this method on two recently released publications datasets (Dimensions COVID-19 dataset and the Allen Institute for AIs CORD-19). The results reveal intriguing information including increased efforts in topics such as social distancing; cross-domain initiatives (e.g. mental health and education); evolving research in medical topics; and the unfolding trajectory of the virus in different territories through publications. The results also demonstrate the need to quickly and automatically enable search and browsing of large corpora. We believe our methodology will improve future large volume visualisation and discovery systems but also hope our visualisation interfaces will currently aid scientists, researchers, and the general public to tackle the numerous issues in the fight against the COVID-19 pandemic.
The Corona Virus Disease 2019 (COVID-19) belongs to human coronaviruses (HCoVs), which spreads rapidly around the world. Compared with new drug development, drug repurposing may be the best shortcut for treating COVID-19. Therefore, we constructed a comprehensive heterogeneous network based on the HCoVs-related target proteins and use the previously proposed deepDTnet, to discover potential drug candidates for COVID-19. We obtain high performance in predicting the possible drugs effective for COVID-19 related proteins. In summary, this work utilizes a powerful heterogeneous network-based deep learning method, which may be beneficial to quickly identify candidate repurposable drugs toward future clinical trials for COVID-19. The code and data are available at https://github.com/stjin-XMU/HnDR-COVID.
The COVID-19 epidemic is considered as the global health crisis of the whole society and the greatest challenge mankind faced since World War Two. Unfortunately, the fake news about COVID-19 is spreading as fast as the virus itself. The incorrect health measurements, anxiety, and hate speeches will have bad consequences on peoples physical health, as well as their mental health in the whole world. To help better combat the COVID-19 fake news, we propose a new fake news detection dataset MM-COVID(Multilingual and Multidimensional COVID-19 Fake News Data Repository). This dataset provides the multilingual fake news and the relevant social context. We collect 3981 pieces of fake news content and 7192 trustworthy information from English, Spanish, Portuguese, Hindi, French and Italian, 6 different languages. We present a detailed and exploratory analysis of MM-COVID from different perspectives and demonstrate the utility of MM-COVID in several potential applications of COVID-19 fake news study on multilingual and social media.
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