The Simons Observatory (SO) is an upcoming polarization-sensitive Cosmic Microwave Background (CMB) experiment on the Cerro Toco Plateau (Chile) with large overlap with other optical and infrared surveys (e.g., DESI, LSST, HSC). To enable the readout of bigO(10,000) detectors in each of the four telescopes of SO, we will employ the microwave SQUID multiplexing technology. With a targeted multiplexing factor of bigO{(1,000)}, microwave SQUID multiplexing has never been deployed on the scale needed for SO. Here we present the design of the cryogenic coaxial cable and RF component chain that connects room temperature readout electronics to superconducting resonators that are coupled to Transition Edge Sensor bolometers operating at sub-Kelvin temperatures. We describe design considerations including cryogenic RF component selection, system linearity, noise, and thermal power dissipation.
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