We investigate the azimuthal angular correlation between the lepton transverse momentum $P_perp$ and the impact parameter $b_perp$ in non-central heavy-ion collisions, where the leptons are produced through two-photon scattering. Among the Fourier harmonic coefficients, a significant $v_4$ asymmetry is found for the typical kinematics at RHIC and LHC with a mild dependence on the $P_perp$, whereas $v_2$ is power suppressed by the lepton mass over $P_perp$. This unique prediction, if confirmed from the experiments, shall provide crucial information on the production mechanism for the dilepton in two-photon processes.
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