The topological lasers, which are immune to imperfections and disorders, have been recently demonstrated based on many kinds of robust edge states, being mostly at microscale. The realization of 2D on-chip topological nanolasers, having the small footprint, low threshold and high energy efficiency, is still to be explored. Here, we report on the first experimental demonstration of the topological nanolaser with high performance in 2D photonic crystal slab. Based on the generalized 2D Su-Schrieffer-Heeger model, a topological nanocavity is formed with the help of the Wannier-type 0D corner state. Laser behaviors with low threshold about 1 $mu W$ and high spontaneous emission coupling factor of 0.25 are observed with quantum dots as the active material. Such performance is much better than that of topological edge lasers and comparable to conventional photonic crystal nanolasers. Our experimental demonstration of the low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for manipulation of photons in classical and quantum regimes.