We analyze the evidence of Majorana zero modes in nanowires that came from tunneling spectroscopy and other experiments, and scout the path to topologically protected states that are of interest for quantum computing. We illustrate the importance of the superconductor-semiconductor interface quality and sketch out where further progress in materials science of these interfaces can take us. Finally, we discuss the prospects of observing more exotic non-Abelian anyons based on the same materials platform, and how to make connections to high energy physics.