Example-guided image synthesis has been recently attempted to synthesize an image from a semantic label map and an exemplary image. In the task, the additional exemplary image serves to provide style guidance that controls the appearance of the synthesized output. Despite the controllability advantage, the previous models are designed on datasets with specific and roughly aligned objects. In this paper, we tackle a more challenging and general task, where the exemplar is an arbitrary scene image that is semantically unaligned to the given label map. To this end, we first propose a new Masked Spatial-Channel Attention (MSCA) module which models the correspondence between two unstructured scenes via cross-attention. Next, we propose an end-to-end network for joint global and local feature alignment and synthesis. In addition, we propose a novel patch-based self-supervision scheme to enable training. Experiments on the large-scale CCOO-stuff dataset show significant improvements over existing methods. Moreover, our approach provides interpretability and can be readily extended to other tasks including style and spatial interpolation or extrapolation, as well as other content manipulation.