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Purpose: Segmentation of organs-at-risk (OARs) is a bottleneck in current radiation oncology pipelines and is often time consuming and labor intensive. In this paper, we propose an atlas-based semi-supervised registration algorithm to generate accurate segmentations of OARs for which there are ground truth contours and rough segmentations of all other OARs in the atlas. To the best of our knowledge, this is the first study to use learning-based registration methods for the segmentation of head and neck patients and demonstrate its utility in clinical applications. Methods: Our algorithm cascades rigid and deformable deformation blocks, and takes on an atlas image (M), set of atlas-space segmentations (S_A), and a patient image (F) as inputs, while outputting patient-space segmentations of all OARs defined on the atlas. We train our model on 475 CT images taken from public archives and Stanford RadOnc Clinic (SROC), validate on 5 CT images from SROC, and test our model on 20 CT images from SROC. Results: Our method outperforms current state of the art learning-based registration algorithms and achieves an overall dice score of 0.789 on our test set. Moreover, our method yields a performance comparable to manual segmentation and supervised segmentation, while solving a much more complex registration problem. Whereas supervised segmentation methods only automate the segmentation process for a select few number of OARs, we demonstrate that our methods can achieve similar performance for OARs of interest, while also providing segmentations for every other OAR on the provided atlas. Conclusions: Our proposed algorithm has significant clinical applications and could help reduce the bottleneck for segmentation of head and neck OARs. Further, our results demonstrate that semi-supervised diffeomorphic registration can be accurately applied to both registration and segmentation problems.
Self-supervised learning (SlfSL), aiming at learning feature representations through ingeniously designed pretext tasks without human annotation, has achieved compelling progress in the past few years. Very recently, SlfSL has also been identified as a promising solution for semi-supervised learning (SemSL) since it offers a new paradigm to utilize unlabeled data. This work further explores this direction by proposing to couple SlfSL with SemSL. Our insight is that the prediction target in SemSL can be modeled as the latent factor in the predictor for the SlfSL target. Marginalizing over the latent factor naturally derives a new formulation which marries the prediction targets of these two learning processes. By implementing this idea through a simple-but-effective SlfSL approach -- rotation angle prediction, we create a new SemSL approach called Conditional Rotation Angle Estimation (CRAE). Specifically, CRAE is featured by adopting a module which predicts the image rotation angle conditioned on the candidate image class. Through experimental evaluation, we show that CRAE achieves superior performance over the other existing ways of combining SlfSL and SemSL. To further boost CRAE, we propose two extensions to strengthen the coupling between SemSL target and SlfSL target in basic CRAE. We show that this leads to an improved CRAE method which can achieve the state-of-the-art SemSL performance.
We propose a large deformation diffeomorphic metric mapping algorithm to align multiple b-value diffusion weighted imaging (mDWI) data, specifically acquired via hybrid diffusion imaging (HYDI), denoted as LDDMM-HYDI. We then propose a Bayesian model for estimating the white matter atlas from HYDIs. We adopt the work given in Hosseinbor et al. (2012) and represent the q-space diffusion signal with the Bessel Fourier orientation reconstruction (BFOR) signal basis. The BFOR framework provides the representation of mDWI in the q-space and thus reduces memory requirement. In addition, since the BFOR signal basis is orthonormal, the L2 norm that quantifies the differences in the q-space signals of any two mDWI datasets can be easily computed as the sum of the squared differences in the BFOR expansion coefficients. In this work, we show that the reorientation of the $q$-space signal due to spatial transformation can be easily defined on the BFOR signal basis. We incorporate the BFOR signal basis into the LDDMM framework and derive the gradient descent algorithm for LDDMM-HYDI with explicit orientation optimization. Additionally, we extend the previous Bayesian atlas estimation framework for scalar-valued images to HYDIs and derive the expectation-maximization algorithm for solving the HYDI atlas estimation problem. Using real HYDI datasets, we show the Bayesian model generates the white matter atlas with anatomical details. Moreover, we show that it is important to consider the variation of mDWI reorientation due to a small change in diffeomorphic transformation in the LDDMM-HYDI optimization and to incorporate the full information of HYDI for aligning mDWI.
Despite the data labeling cost for the object detection tasks being substantially more than that of the classification tasks, semi-supervised learning methods for object detection have not been studied much. In this paper, we propose an Interpolation-based Semi-supervised learning method for object Detection (ISD), which considers and solves the problems caused by applying conventional Interpolation Regularization (IR) directly to object detection. We divide the output of the model into two types according to the objectness scores of both original patches that are mixed in IR. Then, we apply a separate loss suitable for each type in an unsupervised manner. The proposed losses dramatically improve the performance of semi-supervised learning as well as supervised learning. In the supervised learning setting, our method improves the baseline methods by a significant margin. In the semi-supervised learning setting, our algorithm improves the performance on a benchmark dataset (PASCAL VOC and MSCOCO) in a benchmark architecture (SSD).
Recent state-of-the-art semi-supervised learning (SSL) methods use a combination of image-based transformations and consistency regularization as core components. Such methods, however, are limited to simple transformations such as traditional data augmentation or convex combinations of two images. In this paper, we propose a novel learned feature-based refinement and augmentation method that produces a varied set of complex transformations. Importantly, these transformations also use information from both within-class and across-class prototypical representations that we extract through clustering. We use features already computed across iterations by storing them in a memory bank, obviating the need for significant extra computation. These transformations, combined with traditional image-based augmentation, are then used as part of the consistency-based regularization loss. We demonstrate that our method is comparable to current state of art for smaller datasets (CIFAR-10 and SVHN) while being able to scale up to larger datasets such as CIFAR-100 and mini-Imagenet where we achieve significant gains over the state of art (textit{e.g.,} absolute 17.44% gain on mini-ImageNet). We further test our method on DomainNet, demonstrating better robustness to out-of-domain unlabeled data, and perform rigorous ablations and analysis to validate the method.
3D object detection is an important task in computer vision. Most existing methods require a large number of high-quality 3D annotations, which are expensive to collect. Especially for outdoor scenes, the problem becomes more severe due to the sparseness of the point cloud and the complexity of urban scenes. Semi-supervised learning is a promising technique to mitigate the data annotation issue. Inspired by this, we propose a novel semi-supervised framework based on pseudo-labeling for outdoor 3D object detection tasks. We design the Adaptive Class Confidence Selection module (ACCS) to generate high-quality pseudo-labels. Besides, we propose Holistic Point Cloud Augmentation (HPCA) for unlabeled data to improve robustness. Experiments on the KITTI benchmark demonstrate the effectiveness of our method.