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Register a new userAutomatic Annotation of Hip Anatomy in Fluoroscopy for Robust and Efficient 2D/3D Registration
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Fluoroscopy is the standard imaging modality used to guide hip surgery and is therefore a natural sensor for computer-assisted navigation. In order to efficiently solve the complex registration problems presented during navigation, human-assisted annotations of the intraoperative image are typically required. This manual initialization interferes with the surgical workflow and diminishes any advantages gained from navigation. We propose a method for fully automatic registration using annotations produced by a neural network. Neural networks are trained to simultaneously segment anatomy and identify landmarks in fluoroscopy. Training data is obtained using an intraoperatively incompatible 2D/3D registration of hip anatomy. Ground truth 2D labels are established using projected 3D annotations. Intraoperative registration couples an intensity-based strategy with annotations inferred by the network and requires no human assistance. Ground truth labels were obtained in 366 fluoroscopic images across 6 cadaveric specimens. In a leave-one-subject-out experiment, networks obtained mean dice coefficients for left and right hemipelves, left and right femurs of 0.86, 0.87, 0.90, and 0.84. The mean 2D landmark error was 5.0 mm. The pelvis was registered within 1 degree for 86% of the images when using the proposed intraoperative approach with an average runtime of 7 seconds. In comparison, an intensity-only approach without manual initialization, registered the pelvis to 1 degree in 18% of images. We have created the first accurately annotated, non-synthetic, dataset of hip fluoroscopy. By using these annotations as training data for neural networks, state of the art performance in fluoroscopic segmentation and landmark localization was achieved. Integrating these annotations allows for a robust, fully automatic, and efficient intraoperative registration during fluoroscopic navigation of the hip.
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Periacetabular osteotomy is a challenging surgical procedure for treating developmental hip dysplasia, providing greater coverage of the femoral head via relocation of a patients acetabulum. Since fluoroscopic imaging is frequently used in the surgical workflow, computer-assisted X-Ray navigation of osteotomes and the relocated acetabular fragment should be feasible. We use intensity-based 2D/3D registration to estimate the pelvis pose with respect to fluoroscopic images, recover relative poses of multiple views, and triangulate landmarks which may be used for navigation. Existing similarity metrics are unable to consistently account for the inherent mismatch between the preoperative intact pelvis, and the intraoperative reality of a fractured pelvis. To mitigate the effect of this mismatch, we continuously estimate the relevance of each pixel to solving the registration and use these values as weightings in a patch-based similarity metric. Limiting computation to randomly selected subsets of patches results in faster runtimes than existing patch-based methods. A simulation study was conducted with random fragment shapes, relocations, and fluoroscopic views, and the proposed method achieved a 1.7 mm mean triangulation error over all landmarks, compared to mean errors of 3 mm and 2.8 mm for the non-patched and image-intensity-variance-weighted patch similarity metrics, respectively.
This paper focuses on developing efficient and robust evaluation metrics for RANSAC hypotheses to achieve accurate 3D rigid registration. Estimating six-degree-of-freedom (6-DoF) pose from feature correspondences remains a popular approach to 3D rigid registration, where random sample consensus (RANSAC) is a de-facto choice to this problem. However, existing metrics for RANSAC hypotheses are either time-consuming or sensitive to common nuisances, parameter variations, and different application scenarios, resulting in performance deterioration in overall registration accuracy and speed. We alleviate this problem by first analyzing the contributions of inliers and outliers, and then proposing several efficient and robust metrics with different designing motivations for RANSAC hypotheses. Comparative experiments on four standard datasets with different nuisances and application scenarios verify that the proposed metrics can significantly improve the registration performance and are more robust than several state-of-the-art competitors, making them good gifts to practical applications. This work also draws an interesting conclusion, i.e., not all inliers are equal while all outliers should be equal, which may shed new light on this research problem.
Accurate and consistent mental interpretation of fluoroscopy to determine the position and orientation of acetabular bone fragments in 3D space is difficult. We propose a computer assisted approach that uses a single fluoroscopic view and quickly reports the pose of an acetabular fragment without any user input or initialization. Intraoperatively, but prior to any osteotomies, two constellations of metallic ball-bearings (BBs) are injected into the wing of a patients ilium and lateral superior pubic ramus. One constellation is located on the expected acetabular fragment, and the other is located on the remaining, larger, pelvis fragment. The 3D locations of each BB are reconstructed using three fluoroscopic views and 2D/3D registrations to a preoperative CT scan of the pelvis. The relative pose of the fragment is established by estimating the movement of the two BB constellations using a single fluoroscopic view taken after osteotomy and fragment relocation. BB detection and inter-view correspondences are automatically computed throughout the processing pipeline. The proposed method was evaluated on a multitude of fluoroscopic images collected from six cadaveric surgeries performed bilaterally on three specimens. Mean fragment rotation error was 2.4 +/- 1.0 degrees, mean translation error was 2.1 +/- 0.6 mm, and mean 3D lateral center edge angle error was 1.0 +/- 0.5 degrees. The average runtime of the single-view pose estimation was 0.7 +/- 0.2 seconds. The proposed method demonstrates accuracy similar to other state of the art systems which require optical tracking systems or multiple-view 2D/3D registrations with manual input. The errors reported on fragment poses and lateral center edge angles are within the margins required for accurate intraoperative evaluation of femoral head coverage.
We present a novel approach to robustly detect and perceive vehicles in different camera views as part of a cooperative vehicle-infrastructure system (CVIS). Our formulation is designed for arbitrary camera views and makes no assumptions about intrinsic or extrinsic parameters. First, to deal with multi-view data scarcity, we propose a part-assisted novel view synthesis algorithm for data augmentation. We train a part-based texture inpainting network in a self-supervised manner. Then we render the textured model into the background image with the target 6-DoF pose. Second, to handle various camera parameters, we present a new method that produces dense mappings between image pixels and 3D points to perform robust 2D/3D vehicle parsing. Third, we build the first CVIS dataset for benchmarking, which annotates more than 1540 images (14017 instances) from real-world traffic scenarios. We combine these novel algorithms and datasets to develop a robust approach for 2D/3D vehicle parsing for CVIS. In practice, our approach outperforms SOTA methods on 2D detection, instance segmentation, and 6-DoF pose estimation, by 4.5%, 4.3%, and 2.9%, respectively. More details and results are included in the supplement. To facilitate future research, we will release the source code and the dataset on GitHub.
Breast cancer is the malignant tumor that causes the highest number of cancer deaths in females. Digital mammograms (DM or 2D mammogram) and digital breast tomosynthesis (DBT or 3D mammogram) are the two types of mammography imagery that are used in clinical practice for breast cancer detection and diagnosis. Radiologists usually read both imaging modalities in combination; however, existing computer-aided diagnosis tools are designed using only one imaging modality. Inspired by clinical practice, we propose an innovative convolutional neural network (CNN) architecture for breast cancer classification, which uses both 2D and 3D mammograms, simultaneously. Our experiment shows that the proposed method significantly improves the performance of breast cancer classification. By assembling three CNN classifiers, the proposed model achieves 0.97 AUC, which is 34.72% higher than the methods using only one imaging modality.
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