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Register a new userGeneration of swine movement network and analysis of efficient mitigation strategies for African swine fever virus
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Animal movement networks are essential in understanding and containing the spread of infectious diseases in farming industries. Due to its confidential nature, movement data for the US swine farming population is not readily available. Hence, we propose a method to generate such networks from limited data available in the public domain. As a potentially devastating candidate, we simulate the spread of African swine fever virus (ASFV) in our generated network and analyze how the network structure affects the disease spread. We find that high in-degree farm operations (i.e., markets) play critical roles in the disease spread. We also find that high in-degree based targeted isolation and hypothetical vaccinations are more effective for disease control compared to other centrality-based mitigation strategies. The generated networks can be made more robust by validation with more data whenever more movement data will be available.
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African Swine Fever (ASF) is viral infection which causes acute disease in domestic pigs and wild boar. Although the virus does not cause disease in humans, the impact it has on the economy, especially through trade and farming, is substantial. Recent rapid propagation of the (ASF) from East to West of Europe encouraged us to prepare risk assessment for Poland. The early growth estimation can be easily done by matching incidence trajectory to the exponential function, resulting in the approximation of the force of infection. With these calculations the basic reproduction rate of the epidemic, the effective outbreaks detection and elimination times could be estimated. In regression mode, 380 Polish counties (poviats) have been analysed, where 18 (located in Northeast Poland) have been affected (until August 2017) for spatial propagation (risk assessment for future). Mathematical model has been applied by taking into account: swine amount significance, disease vectors (wild boards) significance. We use pseudogravitational models of short and longrange interactions referring to the socio-migratory behavior of wild boars and the pork production chain significance. Spatial modeling in a certain range of parameters proves the existence of a natural protective barrier within boarders of the Congress Poland. The spread of the disease to the Greater Poland should result in the accelerated outbreak of ASF production chain. In the preliminary setup, we perform regression analysis, network outbreak investigation, early epidemic growth estimation and simulate landscape-based propagation.
The paper studies multi-competitive continuous-time epidemic processes in the presence of a shared resource. We consider the setting where multiple viruses are simultaneously prevalent in the population, and the spread occurs due to not only individual-to-individual interaction but also due to individual-to-resource interaction. In such a setting, an individual is either not affected by any of the viruses, or infected by one and exactly one of the multiple viruses. We classify the equilibria into three classes: a) the healthy state (all viruses are eradicated), b) single-virus endemic equilibria (all but one viruses are eradicated), and c) coexisting equilibria (multiple viruses simultaneously infect separate fractions of the population). We provide i) a sufficient condition for exponential (resp. asymptotic) eradication of a virus; ii) a sufficient condition for the existence, uniqueness and asymptotic stability of a single-virus endemic equilibrium; iii) a necessary and sufficient condition for the healthy state to be the unique equilibrium; and iv) for the bi-virus setting (i.e., two competing viruses), a sufficient condition and a necessary condition for the existence of a coexisting equilibrium. Building on these analytical results, we provide two mitigation strategies: a technique that guarantees convergence to the healthy state; and, in a bi-virus setup, a scheme that employs one virus to ensure that the other virus is eradicated. The results are illustrated in a numerical study of a spread scenario in Stockholm city.
The Ebola virus is spreading throughout West Africa and is causing thousands of deaths. In order to quantify the effectiveness of different strategies for controlling the spread, we develop a mathematical model in which the propagation of the Ebola virus through Liberia is caused by travel between counties. For the initial months in which the Ebola virus spreads, we find that the arrival times of the disease into the counties predicted by our model are compatible with World Health Organization data, but we also find that reducing mobility is insufficient to contain the epidemic because it delays the arrival of Ebola virus in each county by only a few weeks. We study the effect of a strategy in which safe burials are increased and effective hospitalisation instituted under two scenarios: (i) one implemented in mid-July 2014 and (ii) one in mid-August---which was the actual time that strong interventions began in Liberia. We find that if scenario (i) had been pursued the lifetime of the epidemic would have been three months shorter and the total number of infected individuals 80% less than in scenario (ii). Our projection under scenario (ii) is that the spreading will stop by mid-spring 2015.
Food webs represent the set of consumer-resource interactions among a set of species that co-occur in a habitat, but most food web studies have omitted parasites and their interactions. Recent studies have provided conflicting evidence on whether including parasites changes food web structure, with some suggesting that parasitic interactions are structurally distinct from those among free-living species while others claim the opposite. Here, we describe a principled method for understanding food web structure that combines an efficient optimization algorithm from statistical physics called parallel tempering with a probabilistic generalization of the empirically well-supported food web niche model. This generative model approach allows us to rigorously estimate the degree to which interactions that involve parasites are statistically distinguishable from interactions among free-living species, whether parasite niches behave similarly to free-living niches, and the degree to which existing hypotheses about food web structure are naturally recovered. We apply this method to the well-studied Flensburg Fjord food web and show that while predation on parasites, concomitant predation of parasites, and parasitic intraguild trophic interactions are largely indistinguishable from free-living predation interactions, parasite-host interactions are different. These results provide a powerful new tool for evaluating the impact of classes of species and interactions on food web structure to shed new light on the roles of parasites in food webs
Containing an epidemic at its origin is the most desirable mitigation. Epidemics have often originated in rural areas, with rural communities among the first affected. Disease dynamics in rural regions have received limited attention, and results of general studies cannot be directly applied since population densities and human mobility factors are very different in rural regions from those in cities. We create a network model of a rural community in Kansas, USA, by collecting data on the contact patterns and computing rates of contact among a sampled population. We model the impact of different mitigation strategies detecting closely connected groups of people and frequently visited locations. Within those groups and locations, we compare the effectiveness of random and targeted vaccinations using a Susceptible-Exposed-Infected-Recovered compartmental model on the contact network. Our simulations show that the targeted vaccinations of only 10% of the sampled population reduced the size of the epidemic by 34.5%. Additionally, if 10% of the population visiting one of the most popular locations is randomly vaccinated, the epidemic size is reduced by 19%. Our results suggest a new implementation of a highly effective strategy for targeted vaccinations through the use of popular locations in rural communities.
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