No Arabic abstract
Limit analysis is a computationally efficient tool to assess the resistance and the failure mode of structures but does not provide any information on the displacement capacity, which is one of the concepts which most affects the seismic safety. Therefore, since many researchers did not consider limit analysis as a possible tool for the seismic assessment of structures, its widespread employment has been prevented. In this paper this common belief is questioned and the authors show that limit analysis can be useful in the evaluation of the seismic performance of frame structures. In particular, to overcome the limitation on the possibility to evaluate the displacements of a structure based on a limit analysis approach, an approximated capacity curve is reconstructed. The latter is based on a limit analysis strategy, which takes into account the second order effects, and evaluates the displacement capacity considering a post-peak softening branch and a threshold on the allowed plastic rotations. Then, based on this simplified capacity curve, an equivalent single degree of freedom system is defined in order to assess the seismic performance of frame structures. The proposed simplified strategy is implemented in a dedicated software and the obtained results are validated with well-established approaches based on nonlinear static analyses, showing the reliability and the computational efficiency of this methodology
Alignment-free sequence analysis approaches provide important alternatives over multiple sequence alignment (MSA) in biological sequence analysis because alignment-free approaches have low computation complexity and are not dependent on high level of sequence identity, however, most of the existing alignment-free methods do not employ true full information content of sequences and thus can not accurately reveal similarities and differences among DNA sequences. We present a novel alignment-free computational method for sequence analysis based on Ramanujan-Fourier transform (RFT), in which complete information of DNA sequences is retained. We represent DNA sequences as four binary indicator sequences and apply RFT on the indicator sequences to convert them into frequency domain. The Euclidean distance of the complete RFT coefficients of DNA sequences are used as similarity measure. To address the different lengths in Euclidean space of RFT coefficients, we pad zeros to short DNA binary sequences so that the binary sequences equal the longest length in the comparison sequence data. Thus, the DNA sequences are compared in the same dimensional frequency space without information loss. We demonstrate the usefulness of the proposed method by presenting experimental results on hierarchical clustering of genes and genomes. The proposed method opens a new channel to biological sequence analysis, classification, and structural module identification.
Public repositories for genome and proteome annotations, such as the Gene Ontology (GO), rarely stores negative annotations, i.e. proteins not possessing a given function. This leaves undefined or ill defined the set of negative examples, which is crucial for training the majority of machine learning methods inferring proteins functions. Automated techniques to choose reliable negative proteins are thereby required to train accurate function prediction models. This study proposes the first extensive analysis of the temporal evolution of protein annotations in the GO repository. Novel annotations registered through the years have been analyzed to verify the presence of annotation patterns in the GO hierarchy. Our research supplied fundamental clues about proteins likely to be unreliable as negative examples, that we verified into a novel algorithm of our own construction, validated on two organisms in a genome wide fashion against approaches proposed to choose negative examples in the context of functional prediction.
This paper describes the model updating procedure implemented in NOSA-ITACA, a finite-element code for the structural analysis of masonry constructions of historical interest. The procedure, aimed at matching experimental frequencies and mode shapes, allows fine-tuning calculation of the free parameters in the model. The numerical method is briefly described, and some issues related to its robustness are addressed. The procedure is then applied to a simple case study and two historical structures in Tuscany, the Clock Tower in Lucca and the Maddalena bridge in Borgo a Mozzano.
During the past two decades, the use of ambient vibrations for modal analysis of structures has increased as compared to the traditional techniques (forced vibrations). The Frequency Domain Decomposition method is nowadays widely used in modal analysis because of its accuracy and simplicity. In this paper, we first present the physical meaning of the FDD method to estimate the modal parameters. We discuss then the process used for the evaluation of the building stiffness deduced from the modal shapes. The models considered here are 1D lumped-mass beams and especially the shear beam. The analytical solution of the equations of motion makes it possible to simulate the motion due to a weak to moderate earthquake and then the inter-storey drift knowing only the modal parameters (modal model). This process is finally applied to a 9-storey reinforced concrete (RC) dwelling in Grenoble (France). We successfully compared the building motion for an artificial ground motion deduced from the model estimated using ambient vibrations and recorded in the building. The stiffness of each storey and the inter-storey drift were also calculated.
In this paper, we develop a framework for solving inverse deformation problems using the FEniCS Project finite element software. We validate our approach with experimental imaging data acquired from a soft silicone beam under gravity. In contrast with inverse iterative algorithms that require multiple solutions of a standard elasticity problem, the proposed method can compute the undeformed configuration by solving only one modified elasticity problem. This modified problem has a complexity comparable to the standard one. The framework is implemented within an open-source pipeline enabling the direct and inverse deformation simulation directly from imaging data. We use the high-level Unified Form Language (UFL) of the FEniCS Project to express the finite element model in variational form and to automatically derive the consistent Jacobian. Consequently, the design of the pipeline is flexible: for example, it allows the modification of the constitutive models by changing a single line of code. We include a complete working example showing the inverse deformation of a beam deformed by gravity as supplementary material.