We discuss the recent progress in extracting partonic functions from the quasi-distribution approach, using twisted mass fermions. This concerns, among others, the investigation of several sources of systematic effects. Their careful analysis is a prerequisite to obtain precise determinations of PDFs from the lattice with realistic estimates of all uncertainties. In these proceedings, we shortly discuss systematic effects in the matching procedure. Moreover, we present preliminary results from our new simulations at the physical point. They involve, additionally, the dynamical strange and charm quarks, as well as a larger volume and a smaller lattice spacing than in our previous computations. In addition, we show first results from computations of generalized parton distributions (GPDs) in the quasi-distribution framework.