The Fourier(-Stieltjes) algebras on locally compact groups are important commutative Banach algebras in abstract harmonic analysis. In this paper we introduce a generalization of the above two algebras via twisting with respect to 2-cocycles on the group. We also define and investigate basic properties of the associated multiplier spaces with respect to a pair of 2-cocycles. We finally prove a twisted version of the result of Bo.{z}ejko/Losert/Ruan characterizing amenability of the underlying locally compact group through the comparison of the twisted Fourier-Stieltjes space with the associated multiplier spaces.
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