An open question in quantum optics is how to manipulate and control complex quantum states in an experimentally feasible way. Here we present concepts for transformations of high-dimensional multi-photonic quantum systems. The proposals rely on two new ideas: (I) a novel high-dimensional quantum non-demolition measurement, (II) the encoding and decoding of the entire quantum transformation in an ancillary state for sharing the necessary quantum information between the involved parties. Many solutions can readily be performed in laboratories around the world, and identify important pathways for experimental research in the near future. The concept has been found using the computer algorithm Melvin for designing computer-inspired quantum experiments. This demonstrates that computer algorithms can inspire new ideas in science, which is a widely unexplored potential.