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Register a new userTowards Domain Invariant Heart Sound Abnormality Detection using Learnable Filterbanks
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Added by
Ahmed Imtiaz Humayun
Publication date
2019
fields
Electronic Engineering
and research's language is
English
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Cardiac auscultation is the most practiced non-invasive and cost-effective procedure for the early diagnosis of heart diseases. While machine learning based systems can aid in automatically screening patients, the robustness of these systems is affected by numerous factors including the stethoscope/sensor, environment, and data collection protocol. This paper studies the adverse effect of domain variability on heart sound abnormality detection and develops strategies to address this problem. Methods: We propose a novel Convolutional Neural Network (CNN) layer, consisting of time-convolutional (tConv) units, that emulate Finite Impulse Response (FIR) filters. The filter coefficients can be updated via backpropagation and be stacked in the front-end of the network as a learnable filterbank. Results: On publicly available multi-domain datasets, the proposed method surpasses the top-scoring systems found in the literature for heart sound abnormality detection (a binary classification task). We utilized sensitivity, specificity, F-1 score and Macc (average of sensitivity and specificity) as performance metrics. Our systems achieved relative improvements of up to 11.84% in terms of MAcc, compared to state-of-the-art methods. Conclusion: The results demonstrate the effectiveness of the proposed learnable filterbank CNN architecture in achieving robustness towards sensor/domain variability in PCG signals. Significance: The proposed methods pave the way for deploying automated cardiac screening systems in diversified and underserved communities.
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This paper proposes a novel framework for the segmentation of phonocardiogram (PCG) signals into heart states, exploiting the temporal evolution of the PCG as well as considering the salient information that it provides for the detection of the heart state. We propose the use of recurrent neural networks and exploit recent advancements in attention based learning to segment the PCG signal. This allows the network to identify the most salient aspects of the signal and disregard uninformative information. The proposed method attains state-of-the-art performance on multiple benchmarks including both human and animal heart recordings. Furthermore, we empirically analyse different feature combinations including envelop features, wavelet and Mel Frequency Cepstral Coefficients (MFCC), and provide quantitative measurements that explore the importance of different features in the proposed approach. We demonstrate that a recurrent neural network coupled with attention mechanisms can effectively learn from irregular and noisy PCG recordings. Our analysis of different feature combinations shows that MFCC features and their derivatives offer the best performance compared to classical wavelet and envelop features. Heart sound segmentation is a crucial pre-processing step for many diagnostic applications. The proposed method provides a cost effective alternative to labour extensive manual segmentation, and provides a more accurate segmentation than existing methods. As such, it can improve the performance of further analysis including the detection of murmurs and ejection clicks. The proposed method is also applicable for detection and segmentation of other one dimensional biomedical signals.
Heart Sound (also known as phonocardiogram (PCG)) analysis is a popular way that detects cardiovascular diseases (CVDs). Most PCG analysis uses supervised way, which demands both normal and abnormal samples. This paper proposes a method of unsupervised PCG analysis that uses beta variational auto-encoder ($beta-text{VAE}$) to model the normal PCG signals. The best performed model reaches an AUC (Area Under Curve) value of 0.91 in ROC (Receiver Operating Characteristic) test for PCG signals collected from the same source. Unlike majority of $beta-text{VAE}$s that are used as generative models, the best-performed $beta-text{VAE}$ has a $beta$ value smaller than 1. Further experiments then find that the introduction of a light weighted KL divergence between distribution of latent space and normal distribution improves the performance of anomaly PCG detection based on anomaly scores resulted by reconstruction loss. The fact suggests that anomaly score based on reconstruction loss may be better than anomaly scores based on latent vectors of samples
Left ventricular assist devices (LVADs) are surgically implanted mechanical pumps that improve survival rates for individuals with advanced heart failure. While life-saving, LVAD therapy is also associated with high morbidity, which can be partially attributed to the difficulties in identifying an LVAD complication before an adverse event occurs. Methods that are currently used to monitor for complications in LVAD-supported individuals require frequent clinical assessments at specialized LVAD centers. Remote analysis of digitally recorded precordial sounds has the potential to provide an inexpensive point-of-care diagnostic tool to assess both device function and the degree of cardiac support in LVAD recipients, facilitating real-time, remote monitoring for early detection of complications. To our knowledge, prior studies of precordial sounds in LVAD-supported individuals have analyzed LVAD noise rather than intrinsic heart sounds, due to a focus on detecting pump complications, and perhaps the obscuring of heart sounds by LVAD noise. In this letter, we describe an adaptive filtering method to remove sounds generated by the LVAD, making it possible to automatically isolate and analyze underlying heart sounds. We present preliminary results describing acoustic signatures of heart sounds extracted from in vivo data obtained from LVAD-supported individuals. These findings are significant as they provide proof-of-concept evidence for further exploration of heart sound analysis in LVAD-supported individuals to identify cardiac abnormalities and changes in LVAD support.
Automatic heart sound abnormality detection can play a vital role in the early diagnosis of heart diseases, particularly in low-resource settings. The state-of-the-art algorithms for this task utilize a set of Finite Impulse Response (FIR) band-pass filters as a front-end followed by a Convolutional Neural Network (CNN) model. In this work, we propound a novel CNN architecture that integrates the front-end bandpass filters within the network using time-convolution (tConv) layers, which enables the FIR filter-bank parameters to become learnable. Different initialization strategies for the learnable filters, including random parameters and a set of predefined FIR filter-bank coefficients, are examined. Using the proposed tConv layers, we add constraints to the learnable FIR filters to ensure linear and zero phase responses. Experimental evaluations are performed on a balanced 4-fold cross-validation task prepared using the PhysioNet/CinC 2016 dataset. Results demonstrate that the proposed models yield superior performance compared to the state-of-the-art system, while the linear phase FIR filterbank method provides an absolute improvement of 9.54% over the baseline in terms of an overall accuracy metric.
In this paper, we present a novel Image Fusion Model (IFM) for ECG heart-beat classification to overcome the weaknesses of existing machine learning techniques that rely either on manual feature extraction or direct utilization of 1D raw ECG signal. At the input of IFM, we first convert the heart beats of ECG into three different images using Gramian Angular Field (GAF), Recurrence Plot (RP) and Markov Transition Field (MTF) and then fuse these images to create a single imaging modality. We use AlexNet for feature extraction and classification and thus employ end to end deep learning. We perform experiments on PhysioNet MIT-BIH dataset for five different arrhythmias in accordance with the AAMI EC57 standard and on PTB diagnostics dataset for myocardial infarction (MI) classification. We achieved an state of an art results in terms of prediction accuracy, precision and recall.
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