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Register a new userDual Adaptive Pyramid Network for Cross-Stain Histopathology Image Segmentation
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Xianxu Hou
Publication date
2019
fields
Informatics Engineering
and research's language is
English
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Supervised semantic segmentation normally assumes the test data being in a similar data domain as the training data. However, in practice, the domain mismatch between the training and unseen data could lead to a significant performance drop. Obtaining accurate pixel-wise label for images in different domains is tedious and labor intensive, especially for histopathology images. In this paper, we propose a dual adaptive pyramid network (DAPNet) for histopathological gland segmentation adapting from one stain domain to another. We tackle the domain adaptation problem on two levels: 1) the image-level considers the differences of image color and style; 2) the feature-level addresses the spatial inconsistency between two domains. The two components are implemented as domain classifiers with adversarial training. We evaluate our new approach using two gland segmentation datasets with H&E and DAB-H stains respectively. The extensive experiments and ablation study demonstrate the effectiveness of our approach on the domain adaptive segmentation task. We show that the proposed approach performs favorably against other state-of-the-art methods.
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Deep neural networks have been a prevailing technique in the field of medical image processing. However, the most popular convolutional neural networks (CNNs) based methods for medical image segmentation are imperfect because they model long-range dependencies by stacking layers or enlarging filters. Transformers and the self-attention mechanism are recently proposed to effectively learn long-range dependencies by modeling all pairs of word-to-word attention regardless of their positions. The idea has also been extended to the computer vision field by creating and treating image patches as embeddings. Considering the computation complexity for whole image self-attention, current transformer-based models settle for a rigid partitioning scheme that potentially loses informative relations. Besides, current medical transformers model global context on full resolution images, leading to unnecessary computation costs. To address these issues, we developed a novel method to integrate multi-scale attention and CNN feature extraction using a pyramidal network architecture, namely Pyramid Medical Transformer (PMTrans). The PMTrans captured multi-range relations by working on multi-resolution images. An adaptive partitioning scheme was implemented to retain informative relations and to access different receptive fields efficiently. Experimental results on three medical image datasets (gland segmentation, MoNuSeg, and HECKTOR datasets) showed that PMTrans outperformed the latest CNN-based and transformer-based models for medical image segmentation.
We propose a Dual-Stream Pyramid Registration Network (referred as Dual-PRNet) for unsupervised 3D medical image registration. Unlike recent CNN-based registration approaches, such as VoxelMorph, which explores a single-stream encoder-decoder network to compute a registration fields from a pair of 3D volumes, we design a two-stream architecture able to compute multi-scale registration fields from convolutional feature pyramids. Our contributions are two-fold: (i) we design a two-stream 3D encoder-decoder network which computes two convolutional feature pyramids separately for a pair of input volumes, resulting in strong deep representations that are meaningful for deformation estimation; (ii) we propose a pyramid registration module able to predict multi-scale registration fields directly from the decoding feature pyramids. This allows it to refine the registration fields gradually in a coarse-to-fine manner via sequential warping, and enable the model with the capability for handling significant deformations between two volumes, such as large displacements in spatial domain or slice space. The proposed Dual-PRNet is evaluated on two standard benchmarks for brain MRI registration, where it outperforms the state-of-the-art approaches by a large margin, e.g., having improvements over recent VoxelMorph [2] with 0.683->0.778 on the LPBA40, and 0.511->0.631 on the Mindboggle101, in term of average Dice score.
Low level features like edges and textures play an important role in accurately localizing instances in neural networks. In this paper, we propose an architecture which improves feature pyramid networks commonly used instance segmentation networks by incorporating low level features in all layers of the pyramid in an optimal and efficient way. Specifically, we introduce a new layer which learns new correlations from feature maps of multiple feature pyramid levels holistically and enhances the semantic information of the feature pyramid to improve accuracy. Our architecture is simple to implement in instance segmentation or object detection frameworks to boost accuracy. Using this method in Mask RCNN, our model achieves consistent improvement in precision on COCO Dataset with the computational overhead compared to the original feature pyramid network.
Recently, deep learning based single image super-resolution(SR) approaches have achieved great development. The state-of-the-art SR methods usually adopt a feed-forward pipeline to establish a non-linear mapping between low-res(LR) and high-res(HR) images. However, due to treating all image regions equally without considering the difficulty diversity, these approaches meet an upper bound for optimization. To address this issue, we propose a novel SR approach that discriminately processes each image region within an image by its difficulty. Specifically, we propose a dual-way SR network that one way is trained to focus on easy image regions and another is trained to handle hard image regions. To identify whether a region is easy or hard, we propose a novel image difficulty recognition network based on PSNR prior. Our SR approach that uses the region mask to adaptively enforce the dual-way SR network yields superior results. Extensive experiments on several standard benchmarks (e.g., Set5, Set14, BSD100, and Urban100) show that our approach achieves state-of-the-art performance.
Much of the recent efforts on salient object detection (SOD) have been devoted to producing accurate saliency maps without being aware of their instance labels. To this end, we propose a new pipeline for end-to-end salient instance segmentation (SIS) that predicts a class-agnostic mask for each detected salient instance. To better use the rich feature hierarchies in deep networks and enhance the side predictions, we propose the regularized dense connections, which attentively promote informative features and suppress non-informative ones from all feature pyramids. A novel multi-level RoIAlign based decoder is introduced to adaptively aggregate multi-level features for better mask predictions. Such strategies can be well-encapsulated into the Mask R-CNN pipeline. Extensive experiments on popular benchmarks demonstrate that our design significantly outperforms existing sArt competitors by 6.3% (58.6% vs. 52.3%) in terms of the AP metric.The code is available at https://github.com/yuhuan-wu/RDPNet.
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