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Register a new userTomographic reconstruction to detect evolving structures
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The need for tomographic reconstruction from sparse measurements arises when the measurement process is potentially harmful, needs to be rapid, or is uneconomical. In such cases, information from previous longitudinal scans of the same object helps to reconstruct the current object while requiring significantly fewer updating measurements. Our work is based on longitudinal data acquisition scenarios where we wish to study new changes that evolve within an object over time, such as in repeated scanning for disease monitoring, or in tomography-guided surgical procedures. While this is easily feasible when measurements are acquired from a large number of projection views, it is challenging when the number of views is limited. If the goal is to track the changes while simultaneously reducing sub-sampling artefacts, we propose (1) acquiring measurements from a small number of views and using a global unweighted prior-based reconstruction. If the goal is to observe details of new changes, we propose (2) acquiring measurements from a moderate number of views and using a more involved reconstruction routine. We show that in the latter case, a weighted technique is necessary in order to prevent the prior from adversely affecting the reconstruction of new structures that are absent in any of the earlier scans. The reconstruction of new regions is safeguarded from the bias of the prior by computing regional weights that moderate the local influence of the priors. We are thus able to effectively reconstruct both the old and the new structures in the test. In addition to testing on simulated data, we have validated the efficacy of our method on real tomographic data. The results demonstrate the use of both unweighted and weighted priors in different scenarios.
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The need for tomographic reconstruction from sparse measurements arises when the measurement process is potentially harmful, needs to be rapid, or is uneconomical. In such cases, prior information from previous longitudinal scans of the same or similar objects helps to reconstruct the current object whilst requiring significantly fewer `updating measurements. However, a significant limitation of all prior-based methods is the possible dominance of the prior over the reconstruction of new localised information that has evolved within the test object. In this paper, we improve the state of the art by (1) detecting potential regions where new changes may have occurred, and (2) effectively reconstructing both the old and new structures by computing regional weights that moderate the local influence of the priors. We have tested the efficacy of our method on synthetic as well as real volume data. The results demonstrate that using weighted priors significantly improves the overall quality of the reconstructed data whilst minimising their impact on regions that contain new information.
Tomographic image reconstruction with deep learning is an emerging field, but a recent landmark study reveals that several deep reconstruction networks are unstable for computed tomography (CT) and magnetic resonance imaging (MRI). Specifically, three kinds of instabilities were reported: (1) strong image artefacts from tiny perturbations, (2) small features missing in a deeply reconstructed image, and (3) decreased imaging performance with increased input data. On the other hand, compressed sensing (CS) inspired reconstruction methods do not suffer from these instabilities because of their built-in kernel awareness. For deep reconstruction to realize its full potential and become a mainstream approach for tomographic imaging, it is thus critically important to meet this challenge by stabilizing deep reconstruction networks. Here we propose an Analytic Compressed Iterative Deep (ACID) framework to address this challenge. ACID synergizes a deep reconstruction network trained on big data, kernel awareness from CS-inspired processing, and iterative refinement to minimize the data residual relative to real measurement. Our study demonstrates that the deep reconstruction using ACID is accurate and stable, and sheds light on the converging mechanism of the ACID iteration under a Bounded Relative Error Norm (BREN) condition. In particular, the study shows that ACID-based reconstruction is resilient against adversarial attacks, superior to classic sparsity-regularized reconstruction alone, and eliminates the three kinds of instabilities. We anticipate that this integrative data-driven approach will help promote development and translation of deep tomographic image reconstruction networks into clinical applications.
Low-dose tomography is highly preferred in medical procedures for its reduced radiation risk when compared to standard-dose Computed Tomography (CT). However, the lower the intensity of X-rays, the higher the acquisition noise and hence the reconstructions suffer from artefacts. A large body of work has focussed on improving the algorithms to minimize these artefacts. In this work, we propose two new techniques, rescaled non-linear least squares and Poisson-Gaussian convolution, that reconstruct the underlying image making use of an accurate or near-accurate statistical model of the noise in the projections. We also propose a reconstruction method when prior knowledge of the underlying object is available in the form of templates. This is applicable to longitudinal studies wherein the same object is scanned multiple times to observe the changes that evolve in it over time. Our results on 3D data show that prior information can be used to compensate for the low-dose artefacts, and we demonstrate that it is possible to simultaneously prevent the prior from adversely biasing the reconstructions of new changes in the test object, via a method called ``re-irradiation. Additionally, we also present two techniques for automated tuning of the regularization parameters for tomographic inversion.
A novel method, utilizing convolutional neural networks (CNNs), is proposed to reconstruct hyperspectral cubes from computed tomography imaging spectrometer (CTIS) images. Current reconstruction algorithms are usually subject to long reconstruction times and mediocre precision in cases of a large number of spectral channels. The constructed CNNs deliver higher precision and shorter reconstruction time than a standard expectation maximization algorithm. In addition, the network can handle two different types of real-world images at the same time -- specifically ColorChecker and carrot spectral images are considered. This work paves the way toward real-time reconstruction of hyperspectral cubes from CTIS images.
The feature extraction methods of radiomics are mainly based on static tomographic images at a certain moment, while the occurrence and development of disease is a dynamic process that cannot be fully reflected by only static characteristics. This study proposes a new dynamic radiomics feature extraction workflow that uses time-dependent tomographic images of the same patient, focuses on the changes in image features over time, and then quantifies them as new dynamic features for diagnostic or prognostic evaluation. We first define the mathematical paradigm of dynamic radiomics and introduce three specific methods that can describe the transformation process of features over time. Three different clinical problems are used to validate the performance of the proposed dynamic feature with conventional 2D and 3D static features.
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