The evolution of the fireball in heavy ion collisions is an isentropic process, meaning that it follows a trajectory of constant entropy per baryon in the phase diagram of the strong interaction. Responsible for the collective acceleration of the fireball is the speed of sound of the system, while fluctuations of conserved charges are encoded in quark-number susceptibilities: together, they leave their imprint in final observables. Here, this isentropic evolution will be analysed within chiral effective models that account for both chiral and center symmetry breaking, two central aspects of QCD. Our discussion focusses on the impact on the isentropic trajectories of the treatment of high-momentum modes, of the meson contribution to thermodynamics and of the number of quark flavours.