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Register a new userRegression Models Using Shapes of Functions as Predictors
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Added by
James Tucker
Publication date
2019
fields
Mathematical Statistics
and research's language is
English
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Functional variables are often used as predictors in regression problems. A commonly-used parametric approach, called {it scalar-on-function regression}, uses the $ltwo$ inner product to map functional predictors into scalar responses. This method can perform poorly when predictor functions contain undesired phase variability, causing phases to have disproportionately large influence on the response variable. One past solution has been to perform phase-amplitude separation (as a pre-processing step) and then use only the amplitudes in the regression model. Here we propose a more integrated approach, termed elastic functional regression model (EFRM), where phase-separation is performed inside the regression model, rather than as a pre-processing step. This approach generalizes the notion of phase in functional data, and is based on the norm-preserving time warping of predictors. Due to its invariance properties, this representation provides robustness to predictor phase variability and results in improved predictions of the response variable over traditional models. We demonstrate this framework using a number of datasets involving gait signals, NMR data, and stock market prices.
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Functional data registration is a necessary processing step for many applications. The observed data can be inherently noisy, often due to measurement error or natural process uncertainty, which most functional alignment methods cannot handle. A pair of functions can also have multiple optimal alignment solutions, which is not addressed in current literature. In this paper, a flexible Bayesian approach to functional alignment is presented, which appropriately accounts for noise in the data without any pre-smoothing required. Additionally, by running parallel MCMC chains, the method can account for multiple optimal alignments via the multi-modal posterior distribution of the warping functions. To most efficiently sample the warping functions, the approach relies on a modification of the standard Hamiltonian Monte Carlo to be well-defined on the infinite-dimensional Hilbert space. This flexible Bayesian alignment method is applied to both simulated data and real data sets to show its efficiency in handling noisy functions and successfully accounting for multiple optimal alignments in the posterior; characterizing the uncertainty surrounding the warping functions.
Nonlinear Mixed effects models are hidden variables models that are widely used in many field such as pharmacometrics. In such models, the distribution characteristics of hidden variables can be specified by including several parameters such as covariates or correlations which must be selected. Recent development of pharmacogenomics has brought averaged/high dimensional problems to the field of nonlinear mixed effects modeling for which standard covariates selection techniques like stepwise methods are not well suited. This work proposes to select covariates and correlation parameters using a penalized likelihood approach. The penalized likelihood problem is solved using a stochastic proximal gradient algorithm to avoid inner-outer iterations. Speed of convergence of the proximal gradient algorithm is improved by the use of component-wise adaptive gradient step sizes. The practical implementation and tuning of the proximal gradient algorithm is explored using simulations. Calibration of regularization parameters is performed by minimizing the Bayesian Information Criterion using particle swarm optimization, a zero order optimization procedure. The use of warm restart and parallelization allows to reduce significantly computing time. The performance of the proposed method compared to the traditional grid search strategy is explored using simulated data. Finally, an application to real data from two pharmacokinetics studies is provided, one studying an antifibrinolitic and the other studying an antibiotic.
We propose a supervised principal component regression method for relating functional responses with high dimensional covariates. Unlike the conventional principal component analysis, the proposed method builds on a newly defined expected integrated residual sum of squares, which directly makes use of the association between functional response and predictors. Minimizing the integrated residual sum of squares gives the supervised principal components, which is equivalent to solving a sequence of nonconvex generalized Rayleigh quotient optimization problems and thus is computationally intractable. To overcome this computational challenge, we reformulate the nonconvex optimization problems into a simultaneous linear regression, with a sparse penalty added to deal with high dimensional predictors. Theoretically, we show that the reformulated regression problem recovers the same supervised principal subspace under suitable conditions. Statistically, we establish non-asymptotic error bounds for the proposed estimators. Numerical studies and an application to the Human Connectome Project lend further support.
This paper presents tests to formally choose between regression models using different derivatives of a functional covariate in scalar-on-function regression. We demonstrate that for linear regression, models using different derivatives can be nested within a model that includes point-impact effects at the end-points of the observed functions. Contrasts can then be employed to test the specification of different derivatives. When nonlinear regression models are defined, we apply a $J$ test to determine the statistical significance of the nonlinear structure between a functional covariate and a scalar response. The finite-sample performance of these methods is verified in simulation, and their practical application is demonstrated using a chemometric data set.
This paper considers the modeling of zero-inflated circular measurements concerning real case studies from medical sciences. Circular-circular regression models have been discussed in the statistical literature and illustrated with various real-life applications. However, there are no models to deal with zero-inflated response as well as a covariate simultaneously. The Mobius transformation based two-stage circular-circular regression model is proposed, and the Bayesian estimation of the model parameters is suggested using the MCMC algorithm. Simulation results show the superiority of the performance of the proposed method over the existing competitors. The method is applied to analyse real datasets on astigmatism due to cataract surgery and abnormal gait related to orthopaedic impairment. The methodology proposed can assist in efficient decision making during treatment or post-operative care.
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