The recent measurements of internal variations of helium in Galactic and extragalactic Globular Clusters (GCs) set binding constraints to the models of formation of Multiple Populations (MPs) in GCs, and gave rise, at the same time, to crucial questions related with the influence of the environment on MP formation as well as with the role played by GCs in the early galactic formation. We present the most recent estimates of helium enrichment in the main populations of a large sample of Galactic and extragalactic GCs.
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