No Arabic abstract
Robustness of deep learning methods for limited angle tomography is challenged by two major factors: a) due to insufficient training data the network may not generalize well to unseen data; b) deep learning methods are sensitive to noise. Thus, generating reconstructed images directly from a neural network appears inadequate. We propose to constrain the reconstructed images to be consistent with the measured projection data, while the unmeasured information is complemented by learning based methods. For this purpose, a data consistent artifact reduction (DCAR) method is introduced: First, a prior image is generated from an initial limited angle reconstruction via deep learning as a substitute for missing information. Afterwards, a conventional iterative reconstruction algorithm is applied, integrating the data consistency in the measured angular range and the prior information in the missing angular range. This ensures data integrity in the measured area, while inaccuracies incorporated by the deep learning prior lie only in areas where no information is acquired. The proposed DCAR method achieves significant image quality improvement: for 120-degree cone-beam limited angle tomography more than 10% RMSE reduction in noise-free case and more than 24% RMSE reduction in noisy case compared with a state-of-the-art U-Net based method.
Computed tomography (CT) has been widely used for medical diagnosis, assessment, and therapy planning and guidance. In reality, CT images may be affected adversely in the presence of metallic objects, which could lead to severe metal artifacts and influence clinical diagnosis or dose calculation in radiation therapy. In this paper, we propose a generalizable framework for metal artifact reduction (MAR) by simultaneously leveraging the advantages of image domain and sinogram domain-based MAR techniques. We formulate our framework as a sinogram completion problem and train a neural network (SinoNet) to restore the metal-affected projections. To improve the continuity of the completed projections at the boundary of metal trace and thus alleviate new artifacts in the reconstructed CT images, we train another neural network (PriorNet) to generate a good prior image to guide sinogram learning, and further design a novel residual sinogram learning strategy to effectively utilize the prior image information for better sinogram completion. The two networks are jointly trained in an end-to-end fashion with a differentiable forward projection (FP) operation so that the prior image generation and deep sinogram completion procedures can benefit from each other. Finally, the artifact-reduced CT images are reconstructed using the filtered backward projection (FBP) from the completed sinogram. Extensive experiments on simulated and real artifacts data demonstrate that our method produces superior artifact-reduced results while preserving the anatomical structures and outperforms other MAR methods.
In transmission X-ray microscopy (TXM) systems, the rotation of a scanned sample might be restricted to a limited angular range to avoid collision to other system parts or high attenuation at certain tilting angles. Image reconstruction from such limited angle data suffers from artifacts due to missing data. In this work, deep learning is applied to limited angle reconstruction in TXMs for the first time. With the challenge to obtain sufficient real data for training, training a deep neural network from synthetic data is investigated. Particularly, the U-Net, the state-of-the-art neural network in biomedical imaging, is trained from synthetic ellipsoid data and multi-category data to reduce artifacts in filtered back-projection (FBP) reconstruction images. The proposed method is evaluated on synthetic data and real scanned chlorella data in $100^circ$ limited angle tomography. For synthetic test data, the U-Net significantly reduces root-mean-square error (RMSE) from $2.55 times 10^{-3}$ {mu}m$^{-1}$ in the FBP reconstruction to $1.21 times 10^{-3}$ {mu}m$^{-1}$ in the U-Net reconstruction, and also improves structural similarity (SSIM) index from 0.625 to 0.920. With penalized weighted least square denoising of measured projections, the RMSE and SSIM are further improved to $1.16 times 10^{-3}$ {mu}m$^{-1}$ and 0.932, respectively. For real test data, the proposed method remarkably improves the 3-D visualization of the subcellular structures in the chlorella cell, which indicates its important value for nano-scale imaging in biology, nanoscience and materials science.
Metal artifact reduction (MAR) in computed tomography (CT) is a notoriously challenging task because the artifacts are structured and non-local in the image domain. However, they are inherently local in the sinogram domain. Thus, one possible approach to MAR is to exploit the latter characteristic by learning to reduce artifacts in the sinogram. However, if we directly treat the metal-affected regions in sinogram as missing and replace them with the surrogate data generated by a neural network, the artifact-reduced CT images tend to be over-smoothed and distorted since fine-grained details within the metal-affected regions are completely ignored. In this work, we provide analytical investigation to the issue and propose to address the problem by (1) retaining the metal-affected regions in sinogram and (2) replacing the binarized metal trace with the metal mask projection such that the geometry information of metal implants is encoded. Extensive experiments on simulated datasets and expert evaluations on clinical images demonstrate that our novel network yields anatomically more precise artifact-reduced images than the state-of-the-art approaches, especially when metallic objects are large.
Deep learning based Quantitative Susceptibility Mapping (QSM) has shown great potential in recent years, outperforming traditional non-learning approaches in speed and accuracy. However, many of the current deep learning approaches are not data consistent, require in vivo training data or do not solve all steps of the QSM processing pipeline. Here we aim to overcome these limitations and developed a framework to solve the QSM processing steps jointly. We developed a new hybrid training data generation method that enables the end-to-end training for solving background field correction and dipole inversion in a data-consistent fashion using a variational network that combines the QSM model term and a learned regularizer. We demonstrate that NeXtQSM overcomes the limitations of previous model-agnostic deep learning methods and show that NeXtQSM offers a complete deep learning based pipeline for computing robust, fast and accurate quantitative susceptibility maps.
Video compression artifact reduction aims to recover high-quality videos from low-quality compressed videos. Most existing approaches use a single neighboring frame or a pair of neighboring frames (preceding and/or following the target frame) for this task. Furthermore, as frames of high quality overall may contain low-quality patches, and high-quality patches may exist in frames of low quality overall, current methods focusing on nearby peak-quality frames (PQFs) may miss high-quality details in low-quality frames. To remedy these shortcomings, in this paper we propose a novel end-to-end deep neural network called non-local ConvLSTM (NL-ConvLSTM in short) that exploits multiple consecutive frames. An approximate non-local strategy is introduced in NL-ConvLSTM to capture global motion patterns and trace the spatiotemporal dependency in a video sequence. This approximate strategy makes the non-local module work in a fast and low space-cost way. Our method uses the preceding and following frames of the target frame to generate a residual, from which a higher quality frame is reconstructed. Experiments on two datasets show that NL-ConvLSTM outperforms the existing methods.