Many machine learning models operate on images, but ignore the fact that images are 2D projections formed by 3D geometry interacting with light, in a process called rendering. Enabling ML models to understand image formation might be key for generalization. However, due to an essential rasterization step involving discrete assignment operations, rendering pipelines are non-differentiable and thus largely inaccessible to gradient-based ML techniques. In this paper, we present {emph DIB-R}, a differentiable rendering framework which allows gradients to be analytically computed for all pixels in an image. Key to our approach is to view foreground rasterization as a weighted interpolation of local properties and background rasterization as a distance-based aggregation of global geometry. Our approach allows for accurate optimization over vertex positions, colors, normals, light directions and texture coordinates through a variety of lighting models. We showcase our approach in two ML applications: single-image 3D object prediction, and 3D textured object generation, both trained using exclusively using 2D supervision. Our project website is: https://nv-tlabs.github.io/DIB-R/
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