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Register a new userDirect Quantification for Coronary Artery Stenosis Using Multiview Learning
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The quantification of the coronary artery stenosis is of significant clinical importance in coronary artery disease diagnosis and intervention treatment. It aims to quantify the morphological indices of the coronary artery lesions such as minimum lumen diameter, reference vessel diameter, lesion length, and these indices are the reference of the interventional stent placement. In this study, we propose a direct multiview quantitative coronary angiography (DMQCA) model as an automatic clinical tool to quantify the coronary artery stenosis from X-ray coronary angiography images. The proposed DMQCA model consists of a multiview module with two attention mechanisms, a key-frame module, and a regression module, to achieve direct accurate multiple-index estimation. The multi-view module comprehensively learns the Spatio-temporal features of coronary arteries through a three-dimensional convolution. The attention mechanisms of each view focus on the subtle feature of the lesion region and capture the important context information. The key-frame module learns the subtle features of the stenosis through successive dilated residual blocks. The regression module finally generates the indices estimation from multiple features.
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Coronary artery disease (CAD) has posed a leading threat to the lives of cardiovascular disease patients worldwide for a long time. Therefore, automated diagnosis of CAD has indispensable significance in clinical medicine. However, the complexity of coronary artery plaques that cause CAD makes the automatic detection of coronary artery stenosis in Coronary CT angiography (CCTA) a difficult task. In this paper, we propose a Transformer network (TR-Net) for the automatic detection of significant stenosis (i.e. luminal narrowing > 50%) while practically completing the computer-assisted diagnosis of CAD. The proposed TR-Net introduces a novel Transformer, and tightly combines convolutional layers and Transformer encoders, allowing their advantages to be demonstrated in the task. By analyzing semantic information sequences, TR-Net can fully understand the relationship between image information in each position of a multiplanar reformatted (MPR) image, and accurately detect significant stenosis based on both local and global information. We evaluate our TR-Net on a dataset of 76 patients from different patients annotated by experienced radiologists. Experimental results illustrate that our TR-Net has achieved better results in ACC (0.92), Spec (0.96), PPV (0.84), F1 (0.79) and MCC (0.74) indicators compared with the state-of-the-art methods. The source code is publicly available from the link (https://github.com/XinghuaMa/TR-Net).
In stable coronary artery disease (CAD), reduction in mortality and/or myocardial infarction with revascularization over medical therapy has not been reliably achieved. Coronary arteries are usually extracted to perform stenosis detection. We aim to develop an automatic algorithm by deep learning to extract coronary arteries from ICAs.In this study, a multi-input and multi-scale (MIMS) U-Net with a two-stage recurrent training strategy was proposed for the automatic vessel segmentation. Incorporating features such as the Inception residual module with depth-wise separable convolutional layers, the proposed model generated a refined prediction map with the following two training stages: (i) Stage I coarsely segmented the major coronary arteries from pre-processed single-channel ICAs and generated the probability map of vessels; (ii) during the Stage II, a three-channel image consisting of the original preprocessed image, a generated probability map, and an edge-enhanced image generated from the preprocessed image was fed to the proposed MIMS U-Net to produce the final segmentation probability map. During the training stage, the probability maps were iteratively and recurrently updated by feeding into the neural network. After segmentation, an arterial stenosis detection algorithm was developed to extract vascular centerlines and calculate arterial diameters to evaluate stenotic level. Experimental results demonstrated that the proposed method achieved an average Dice score of 0.8329, an average sensitivity of 0.8281, and an average specificity of 0.9979 in our dataset with 294 ICAs obtained from 73 patient. Moreover, our stenosis detection algorithm achieved a true positive rate of 0.6668 and a positive predictive value of 0.7043.
Coronary angiography is an indispensable assistive technique for cardiac interventional surgery. Segmentation and extraction of blood vessels from coronary angiography videos are very essential prerequisites for physicians to locate, assess and diagnose the plaques and stenosis in blood vessels. This article proposes a new video segmentation framework that can extract the clearest and most comprehensive coronary angiography images from a video sequence, thereby helping physicians to better observe the condition of blood vessels. This framework combines a 3D convolutional layer to extract spatial--temporal information from a video sequence and a 2D CE--Net to accomplish the segmentation task of an image sequence. The input is a few continuous frames of angiographic video, and the output is a mask of segmentation result. From the results of segmentation and extraction, we can get good segmentation results despite the poor quality of coronary angiography video sequences.
The segmentation of coronary arteries by convolutional neural network is promising yet requires a large amount of labor-intensive manual annotations. Transferring knowledge from retinal vessels in widely-available public labeled fundus images (FIs) has a potential to reduce the annotation requirement for coronary artery segmentation in X-ray angiograms (XAs) due to their common tubular structures. However, it is challenged by the cross-anatomy domain shift due to the intrinsically different vesselness characteristics in different anatomical regions under even different imaging protocols. To solve this problem, we propose a Semi-Supervised Cross-Anatomy Domain Adaptation (SS-CADA) which requires only limited annotations for coronary arteries in XAs. With the supervision from a small number of labeled XAs and publicly available labeled FIs, we propose a vesselness-specific batch normalization (VSBN) to individually normalize feature maps for them considering their different cross-anatomic vesselness characteristics. In addition, to further facilitate the annotation efficiency, we employ a self-ensembling mean-teacher (SEMT) to exploit abundant unlabeled XAs by imposing a prediction consistency constraint. Extensive experiments show that our SS-CADA is able to solve the challenging cross-anatomy domain shift, achieving accurate segmentation for coronary arteries given only a small number of labeled XAs.
The reconstruction of three-dimensional models of coronary arteries is of great significance for the localization, evaluation and diagnosis of stenosis and plaque in the arteries, as well as for the assisted navigation of interventional surgery. In the clinical practice, physicians use a few angles of coronary angiography to capture arterial images, so it is of great practical value to perform 3D reconstruction directly from coronary angiography images. However, this is a very difficult computer vision task due to the complex shape of coronary blood vessels, as well as the lack of data set and key point labeling. With the rise of deep learning, more and more work is being done to reconstruct 3D models of human organs from medical images using deep neural networks. We propose an adversarial and generative way to reconstruct three dimensional coronary artery models, from two different views of angiographic images of coronary arteries. With 3D fully supervised learning and 2D weakly supervised learning schemes, we obtained reconstruction accuracies that outperform state-of-art techniques.
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