The Cherenkov Telescope Array (CTA) will be the major global observatory for VHE gamma-ray astronomy over the next decade and beyond. It will be an explorer of the extreme universe, with a broad scientific potential: from understanding the role of relativistic cosmic particles, to the search for dark matter. Covering photon energies from 20 GeV to 300 TeV, and with an angular resolution unique in the field, of about 1 arc min, CTA will improve on all aspects of the performance with respect to current instruments, surveying the high energy sky hundreds of times faster than previous TeV telescopes, and with a much deeper view. The very large collection area of CTA makes it an important probe of transient phenomena. The first CTA telescope has just been inaugurated in the Canary Islands, Spain, and as more telescopes are added in the coming years, scientific operation will start. It is evident that CTA will have important synergies with many of the new generation astronomical and astroparticle observatories. In this talk we will review the CTA science case from the point of view of its synergies with other instruments and facilities, highlighting the CTA needs in terms of external data, as well as the opportunities and strategies for cooperation to achieve the basic CTA science goals.
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