Upcoming synoptic surveys are set to generate an unprecedented amount of data. This requires an automatic framework that can quickly and efficiently provide classification labels for several new object classification challenges. Using data describing 11 types of variable stars from the Catalina Real-Time Transient Surveys (CRTS), we illustrate how to capture the most important information from computed features and describe detailed methods of how to robustly use Information Theory for feature selection and evaluation. We apply three Machine Learning (ML) algorithms and demonstrate how to optimize these classifiers via cross-validation techniques. For the CRTS dataset, we find that the Random Forest (RF) classifier performs best in terms of balanced-accuracy and geometric means. We demonstrate substantially improved classification results by converting the multi-class problem into a binary classification task, achieving a balanced-accuracy rate of $sim$99 per cent for the classification of ${delta}$-Scuti and Anomalous Cepheids (ACEP). Additionally, we describe how classification performance can be improved via converting a flat-multi-class problem into a hierarchical taxonomy. We develop a new hierarchical structure and propose a new set of classification features, enabling the accurate identification of subtypes of cepheids, RR Lyrae and eclipsing binary stars in CRTS data.
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