The gas depletion factor $gamma(z)$, i.e., the average ratio of the gas mass fraction to the cosmic mean baryon fraction of galaxy clusters, plays a very important role in the cosmological application of the gas mass fraction measurements. In this paper, using the newest catalog of 182 galaxy clusters detected by the Atacama Cosmology Telescope (ACT) Polarization experiment, we investigate the possible redshift evolution of $gamma(z)$ through a new cosmology-independent method. The method is based on non-parametric reconstruction using the measurements of Hubble parameters from cosmic chronometers. Unlike hydrodynamical simulations suggesting constant depletion factor, our results reveal the trend of $gamma(z)$ decreasing with redshift. This result is supported by a parametric model fit as well as by calculations on the reduced ACTPol sample and on the alternative sample of 91 SZ clusters reported earlier in ACT compilation. Discussion of possible systematic effects leaves an open question about validity of the empirical relation $M_{tot}$-$f_{gas}$ obtained on very close clusters. These results might pave the way to explore the hot gas fraction within large radii of galaxy clusters as well as its possible evolution with redshift, which should be studied further on larger galaxy cluster samples in the upcoming X-ray/SZ cluster surveys.
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