We study direct detection bounds on cosmic ray-upscattered dark matter in simplified models including light mediators. We find that the energy dependence in the scattering cross section is significant, and produces stronger bounds than previously found (which assumed constant cross sections) by many orders of magnitude at low DM mass. Finally, we compute the neutrino-floor that will limit future direct detection searches for cosmic ray-upscattered dark matter. While we focus on vector interactions for illustration, we emphasize that the energy dependence is critical in determining accurate bounds on any particle physics model of Dark Matter-CR interactions from experimental data on this scenario.