Many quantum statistical models are most conveniently formulated in terms of non-orthonormal bases. This is the case, for example, when mixtures and superpositions of coherent states are involved. In these instances, we show that the analytical evaluation of the quantum Fisher information may be greatly simplified by bypassing both the diagonalization of the density matrix and the orthogonalization of the basis. The key ingredient in our method is the Gramian matrix (i.e. the matrix of scalar products between basis elements), which may be interpreted as a metric tensor for index contraction. As an application, we derive novel analytical results for several estimation problems involving noisy Schroedinger cat states.
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