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Register a new userLow-dose ionizing radiation exposure during pregnancy induces behavioral impairment and lower weight gain in adult rats
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Rodrigo Sanchez Giarola Dr.
Publication date
2019
fields
Physics
and research's language is
English
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Low-dose ionizing radiation may induce far-reaching consequences in human, especially regarding intrauterine development. Many studies have documented that the risks of in utero irradiation remain controversial and no effect is reported at doses below 50 mGy. Animal models are often used to clarify the non-fully understood impact of intrauterine irradiation and allow the manipulation of several experimental setups, making possible the analysis of a wide range of end points. We investigated the impact of in utero low-dose X-ray irradiation on postnatal development in rat offspring through a set of well-established behavioral parameters and weight gain. To investigate the hypothesis of postnatal behavioral and physiological alterations due to prenatal low-dose ionizing radiation we exposed pregnant Wistar to 15 mGy of X-rays on gestational days 8 and 15 and control mothers. This low-dose value into diagnostic range can be achieved in a single radiological exam. Four male animals were select from each litter. At infant age, eye-opening test and negative geotaxis tests were performed. Animals were tested at postnatal ages 30 and 70 days in open field, elevated plus-maze, and hole board tests. We evaluated the weight gain of all animals throughout the experiment. The results presented differences between irradiated and non-irradiated animals. Exposed animals presented lower weight gain in adult life, impairment in central nervous system since infant phase, behavioral alterations persisting into later life, and motor coordination impairment. Effects at doses under 100 mGy have not been reported, however, the present study demonstrate that 15 mGy intrauterine exposure was able to generate deleterious effects.
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