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Register a new userA Sub-mm$^3$ Ultrasonic Free-floating Implant for Multi-mote Neural Recording
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A 0.8 mm$^3$ wireless, ultrasonically powered, free-floating neural recording implant is presented. The device is comprised only of a 0.25 mm$^2$ recording IC and a single piezoceramic resonator that is used for both power harvesting and data transmission. Uplink data transmission is performed by analog amplitude modulation of the ultrasound echo. Using a 1.78 MHz main carrier, >35 kbps/mote equivalent uplink data rate is achieved. A technique to linearize the echo amplitude modulation is introduced, resulting in <1.2% static nonlinearity of the received signal over a $pm$10 mV input range. The IC dissipates 37.7 $mu$W, while the neural recording front-end consumes 4 $mu$W and achieves a noise floor of 5.3 $mu$V$_{rms}$ in a 5 kHz bandwidth. This work improves sub-mm recording mote depth by >2.5x, resulting in the highest measured depth/volume ratio by $sim$3x. Orthogonal subcarrier modulation enables simultaneous operation of multiple implants, using a single-element ultrasound external transducer. Dual-mote simultaneous power up and data transmission is demonstrated at a rate of 7 kS/s at the depth of 50 mm.
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Neural stimulation is a powerful technique for modulating physiological functions and for writing information into the nervous system as part of brain-machine interfaces. Current clinically approved neural stimulators require batteries and are many cubic centimetres in size -- typically much larger than their intended targets. We present a complete wireless neural stimulation system consisting of a 1.7 mm3 wireless, batteryless, leadless implantable stimulator (the mote), an ultrasonic wireless link for power and bi-directional communication, and a hand-held external transceiver. The mote consists of a piezoceramic transducer, an energy storage capacitor, and a stimulator integrated circuit (IC). The IC harvests ultrasonic power with high efficiency, decodes stimulation parameter downlink data, and generates current-controlled stimulation pulses. Stimulation parameters are time-encoded on the fly through the wireless link rather than being programmed and stored on the mote, reducing power consumption and on-chip memory requirements and enabling complex stimulation protocols with high-temporal resolution and low-latency feedback for use in closed-loop stimulation. Uplink data indicates whether the mote is currently stimulating; it is encoded by the mote via backscatter modulation and is demodulated at the external transceiver. We show that the mote operates at an acoustic intensity that is 7.8% of the FDA limit for diagnostic ultrasound and characterize the acoustic wireless links robustness to expected real-world misalignment. We demonstrate the in vivo performance of the system with motes acutely implanted with a cuff on the sciatic nerve of anesthetized rats and show highly repeatable stimulation across a wide range of physiological responses.
The advent of deep learning has considerably accelerated machine learning development. The deployment of deep neural networks at the edge is however limited by their high memory and energy consumption requirements. With new memory technology available, emerging Binarized Neural Networks (BNNs) are promising to reduce the energy impact of the forthcoming machine learning hardware generation, enabling machine learning on the edge devices and avoiding data transfer over the network. In this work, after presenting our implementation employing a hybrid CMOS - hafnium oxide resistive memory technology, we suggest strategies to apply BNNs to biomedical signals such as electrocardiography and electroencephalography, keeping accuracy level and reducing memory requirements. We investigate the memory-accuracy trade-off when binarizing whole network and binarizing solely the classifier part. We also discuss how these results translate to the edge-oriented Mobilenet~V1 neural network on the Imagenet task. The final goal of this research is to enable smart autonomous healthcare devices.
This paper presents a wireless neural recording system featuring energy-efficient data compression and encryption. An ultra-high efficiency is achieved by leveraging compressed sensing (CS) for simultaneous data compression and encryption. CS enables sub-Nyquist sampling of neural signals by taking advantage of its intrinsic sparsity. It simultaneously encrypts the data with the sampling matrix being the cryptographic key. To share the key over an insecure wireless channel, we implement an elliptic-curve cryptography (ECC) based key exchanging protocol. The CS operation is executed in a custom-designed IC fabricated in 180nm CMOS technology. Mixed-signal circuits are designed to optimize the power efficiency of the matrix-vector multiplication (MVM) of the CS operation. The ECC algorithm is implemented in a low-power Cortex-M0 microcontroller (MCU). To be protected from timing and power analysis attacks, the implementation avoids possible data-dependent branches and also employs a randomized ECC initialization. At a compression ratio of 8x, the average correlated coefficient between the reconstructed signals and the uncompressed signals is 0.973, while the ciphertext-only attacks (CoA) achieve no better than 0.054 over 200,000 attacks. The prototype achieves a 35x power saving compared with conventional implementation in low-power MCUs. This work demonstrates a promising solution for future chronic neural recording systems with requirements in high energy efficiency and security.
Genomic complexity can be used as a clock with which the moment in which life originated can be measured. Some authors who have studied this problem have come to the conclusion that it is not possible that terrestrial life originated here and that, in reality, life originated giga-years ago, before the solar system existed. If we accept this conclusion there is no other option than to admit that panspermia is something viable.The goal of this study is to propose a viable hypothesis for the transport of SLF from one planetary system to another. During the formation period of a planetary system giant planets can eject planets the size of the Earth, or larger, turning them into free-floating planets in interstellar space. These free-floating planets have also been called free floaters. If a free floater, which has developed life, enters a lifeless planetary system, it can seed the worlds of this system with SLF dragged by the stellar wind from one planet to another or by great impacts on the free planet. To support this hypothesis, I calculate the probability that one free floater reaches the planets zone of a planetary system, and also it was calculated the time it remains within the planetary zone in order to see if there is enough time to seed the host system.The probability of a free floater in the galaxy, within the region of the Sun, entering the planet zone of a system is 2.8x10-4, i.e., that {sim}3 of 10,000 free planets manage to enter some planetary system. At the galactocentric distance from the Sun I calculated that there are 21,495 free floaters floating around the galactic center. Hence, 6 free-floating planets manage to enter in planetary systems every galaxy rotation. Since the galaxy has rotated 54 times since its formation, then, {sim} 324 free floaters have entered some planetary system at the galactocentric distance of the Sun.
The use of wireless implanted medical devices (IMDs) is growing because they facilitate continuous monitoring of patients during normal activities, simplify medical procedures required for data retrieval and reduce the likelihood of infection associated with trailing wires. However, most of the state-of-the-art IMDs are passive and offline devices. One of the key obstacles to an active and online IMD is the infeasibility of real-time, high-quality video broadcast from the IMD. Such broadcast would help develop innovative devices such as a video-streaming capsule endoscopy (CE) pill with therapeutic intervention capabilities. State-of-the-art IMDs employ radio-frequency electromagnetic waves for information transmission. However, high attenuation of RF-EM waves in tissues and federal restrictions on the transmit power and operable bandwidth lead to fundamental performance constraints for IMDs employing RF links, and prevent achieving high data rates that could accomodate video broadcast. In this work, ultrasonic waves were used for video transmission and broadcast through biological tissues. The proposed proof-of-concept system was tested on a porcine intestine ex vivo and a rabbit in vivo. It was demonstrated that using a millimeter-sized, implanted biocompatible transducer operating at 1.1-1.2 MHz, it was possible to transmit endoscopic video with high resolution (1280 pixels by 720 pixels) through porcine intestine wrapped with bacon, and to broadcast standard definition (640 pixels by 480 pixels) video near real-time through rabbit abdomen in vivo. A media repository that includes experimental demonstrations and media files accompanies this paper. The accompanying media repository can be found at this link: https://bit.ly/3wuc7tk.
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