For the first time, we explore the tightly coupled interior-magnetosphere system of Mercury by employing a three-dimensional ten-moment multifluid model. This novel fluid model incorporates the non-ideal effects including the Hall effect, inertia, and tensorial pressures that are critical for collisionless magnetic reconnection; therefore, it is particularly well suited for investigating $collisionless$ magnetic reconnection in Mercurys magnetotail and at the planets magnetopause. The model is able to reproduce the observed magnetic field vectors, field-aligned currents, and cross-tail current sheet asymmetry (beyond the MHD approach) and the simulation results are in good agreement with spacecraft observations. We also study the magnetospheric response of Mercury to a hypothetical extreme event with an enhanced solar wind dynamic pressure, which demonstrates the significance of induction effects resulting from the electromagnetically-coupled interior. More interestingly, plasmoids (or flux ropes) are formed in Mercurys magnetotail during the event, indicating the highly dynamic nature of Mercurys magnetosphere.